Evidence map›Paper›PMID 41767248›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Plant-derived nanovesicles from

Maneea Moubarak, Emese Szilágyi-Tolnai, Ani Barbulova, Immacolata Fiume, Ildikó Kovács-Forgács, Judit Homoki, Georgina Pesti-Asbóth, Endre Szilágyi, Ramila Mammadova, Matic Kisovec and 5 more

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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maneea Moubarak *Extracellular Vesicles and Mass Spectrometry Laboratory, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy.
Emese Szilágyi-Tolnai *Complex Systems and Microbiome-Innovations Centre, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Ani BarbulovaExtracellular Vesicles and Mass Spectrometry Laboratory, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy.
Immacolata FiumeExtracellular Vesicles and Mass Spectrometry Laboratory, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy.
Ildikó Kovács-ForgácsComplex Systems and Microbiome-Innovations Centre, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Judit Homoki *Complex Systems and Microbiome-Innovations Centre, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Georgina Pesti-AsbóthComplex Systems and Microbiome-Innovations Centre, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Endre SzilágyiComplex Systems and Microbiome-Innovations Centre, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Ramila MammadovaExtracellular Vesicles and Mass Spectrometry Laboratory, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy.
Matic KisovecDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
Marjetka PodobnikDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
Dávid PappMTA-ELTE Lendület Ion Mobility Mass Spectrometry Research Group, Institute of Chemistry, ELTE Eötvös Loránd University, Budapest, Hungary.
Gitta SchlosserMTA-ELTE Lendület Ion Mobility Mass Spectrometry Research Group, Institute of Chemistry, ELTE Eötvös Loránd University, Budapest, Hungary.
Judit Remenyik *Complex Systems and Microbiome-Innovations Centre, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Gabriella Pocsfalvi *Extracellular Vesicles and Mass Spectrometry Laboratory, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endothelial dysfunction is increasingly recognized as an early and central event in the onset of cardiovascular and neurodegenerative diseases. Methods: PDNVs were isolated from Results: Ginkgo PDNV isolates comprise a heterogeneous population of nanometer sized particles, including vesicles with single and double layers. Proteomics revealed seed storage proteins (legumin and ginnacin) and membrane-associated ATPases, HSP90, catalase, phosphoenolpyruvate carboxylase (PEPC), and eEF1A. PDNVs were non-toxic up to 50 μg/mL; at 100 μg/mL, they enhanced mitochondrial activity but triggered early apoptosis and necrosis. PDNVs did not increase ROS production, even in the presence of H Conclusion: Ginkgo seed-derived PDNVs exhibit vascular-protective and anti-inflammatory properties, supporting their potential as safe, multifunctional agents for endothelial modulation. Further studies are warranted to explore their therapeutic applications in vascular biology.

Indexed as

endothelial dysfunctionendothelial inflammationGinkgo bilobaplant-derived nanovesiclesproteomicsvascular protection

Identifiers

PMID41767248
PMCPMC12946737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.