ArticleJournal of nutrition and metabolism2026
Gut Microbiota Alterations in Hypothyroidism: A Pilot Study Revealing Increased Abundance of Specific Bacterial Genera.
Article in Journal of nutrition and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Gut Microbiota Alterations in Hypothyroidism: A Pilot Study Revealing Increased Abundance of Specific Bacterial Genera.Journal of nutrition and metabolism · 2026Article
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5 authors.
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Abstract
Background: Hypothyroidism (HT) is a prevalent thyroid disorder characterized by insufficient thyroid hormone production, leading to metabolic complications. Emerging research suggests a link between gut microbiota and thyroid regulation, positing that alterations in gut bacterial populations may contribute to HT's development and progression. This study aimed to investigate these associations by comparing gut microbiota compositions between individuals with HT and healthy adults, potentially refining diagnostic tools and therapeutic strategies. Methods: In this pilot study conducted between 2019 and 2023, 15 hypothyroid patients and 15 age- and gender-matched healthy controls participated in the study. Exclusion criteria were applied to eliminate confounding factors. Anthropometric data were collected, and stool samples underwent microbial analysis. Total bacterial DNA was extracted, and quantitative real-time PCR targeting 16S rRNA genes across eight bacterial genera was performed. The Mann-Whitney Results: No significant differences were observed in baseline demographic and anthropometric characteristics between groups. However, hypothyroid patients exhibited significantly elevated levels of Conclusion: This pilot study provides preliminary indications of a possible role of gut microbiota in the pathophysiology of HT. Variations in bacterial composition suggest a significant influence of gut health on thyroid regulation. Future studies with larger cohorts are needed to explore the biological pathways linking the gut microbiome to thyroid function, which may lead to novel microbiota-targeted therapeutic approaches.
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