Evidence map›Paper›PMID 41767216›Full record

ArticleTheScientificWorldJournal2026

Bioactivity and Regenerative Potential of Cannabidiol in Human Dental Pulp Stem Cells: A Scoping Review of In Vitro Studies.

Lorena Gomes Guimarães, Wesley Viana de Sousa, Silmara de Andrade Silva, Christianne Velozo, Carolina Viana Vasco Lyra, Larissa Sousa Rangel, Maria Alice Lopes Pereira, Diana Albuquerque

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lorena Gomes GuimarãesDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0002-5251-712X
Wesley Viana de SousaDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0003-2038-1616
Silmara de Andrade SilvaDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0001-9948-636X
Christianne VelozoDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0001-9651-3043
Carolina Viana Vasco LyraDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0002-5474-6815
Larissa Sousa RangelDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0003-0607-488X
Maria Alice Lopes PereiraDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0001-9790-4636
Diana AlbuquerqueDepartment of Restorative Dentistry and Endodontics, Dental College of Pernambuco, University of Pernambuco, Recife, Pernambuco, Brazil, ufpe.br.ORCID https://orcid.org/0000-0002-7897-2489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cannabidiol (CBD), a nonpsychoactive compound derived from Methods: The review followed the Arksey and O'Malley framework, supported by the JBI Manual and PRISMA-ScR guidelines. The protocol was registered on OSF (osf.io/zfhca/). Comprehensive searches were conducted from January to June 2025 in PubMed, EMBASE, BVS, Scopus, Web of Science, ScienceDirect, and SciELO. Only studies published in English were included. Results: Thirty articles were identified, and three in vitro studies met the eligibility criteria. At low concentrations (0.1-5 Conclusion: CBD shows promise as a bioactive molecule in regenerative endodontics, supporting mineralization, regulating inflammatory mediators, and promoting critical cellular activities in hDPSCs. Nevertheless, the available evidence is limited and further preclinical and clinical studies are essential to develop therapeutic protocols and assess long-term safety. These preliminary findings indicate CBD as a novel candidate for regenerative strategies in endodontics.

Indexed as

CannabidiolDental PulpRegenerationStem CellsCell DifferentiationCell ProliferationHumansOsteogenesisCannabidiolcannabidiolcell differentiationdental pulpendodonticsstem cells

Identifiers

PMID41767216
PMCPMC12937086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.