Evidence map›Paper›PMID 41767176›Full record

ArticleOphthalmology science2026

Staging of Keratoconus Indices Based on Localized Corneal Biomechanics Stress-Strain Index Map.

Rui Ning, Yuechen Ren, Jinxuan Xiahou, Shuoyu Xu, Kexin Li, Yiran Wang, Xinning Yang, Zheng Li, Xingtao Zhou, Elsheikh Ahmed and 2 more

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Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Rui NingEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yuechen RenDepartment of Ophthalmology, Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Jiaxing, China.
Jinxuan XiahouEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Shuoyu XuEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Kexin LiEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yiran WangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xinning YangSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Zheng LiEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xingtao ZhouEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Elsheikh AhmedSchool of Engineering, University of Liverpool, Liverpool, United Kingdom.
Xiaoying WangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Jinhai HuangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To assess Stress-Strain Index (SSI) map parameters and to establish a new corneal-biomechanics-based staging (CBBS) system and the diurnal variation of SSI. Design: Hospital-based cross-sectional study. Subjects: Seventy-eight keratoconus subjects. Methods: A total of 78 keratoconus (KC) subjects were included in this study. All subjects had corneal tomography (Pentacam HR, Oculus) and biomechanical measurements (Corvis ST, Oculus) 5 times a day, which were at 8:30, 11:30, 14:30, 17:30, and 20:30. Stress-Strain Index value was obtained from Corvis ST, and SSI map parameters were derived from a customized SSI map generator (Matlab runtime 9.8). An analysis of variance was used to compare the SSI map parameters among varying stages of KC groups. The best performing parameters according to the Youden index were subsequently used to create the CBBS system. Cohen κ statistics and contingency tables were used to compare CBBS and topographic KC classification (TKC) systems. Main Outcome Measures: Stress-Strain Index map parameters were used for analysis: mean inside cone SSI, mean outside cone SSI, minimum SSI, and maximum SSI. Results: Significant diurnal variations were observed in mean inside cone SSI ( Conclusions: A new corneal-biomechanics-based KC staging system was established on the basis of localized corneal biomechanics (mean inside cone SSI). There was no clinically significant diurnal variation in localized corneal biomechanics based on SSI map parameters. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

Diurnal variationKeratoconusLocalized corneal biomechanicsStage

Identifiers

PMID41767176
PMCPMC12938849

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