ArticleKidney diseases (Basel, Switzerland)
Navigating Drug-Related Problems in Hemodialysis Patients across Dual Healthcare Systems: Bridging the Gaps for Optimal Medication Safety.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Drug-related problems (DRPs) are common in hemodialysis (HD) patients, but the impact of different healthcare delivery models on DRP prevalence, characteristics, and medication-related outcomes remains underexplored. This study aimed to investigate and compare DRP prevalence and characteristics among HD patients across two healthcare settings. Methods: This prospective cross-sectional study involved adult chronic HD patients from hospital-based (with pharmacist-led medication management program) and nonhospital-based (without) ambulatory centers. Patients on temporary HD or who had language barrier were excluded. Clinical characteristics and DRP data, identified through structured clinical review and classified using Pharmaceutical Care Network Europe (version 9.0), were analyzed using descriptive statistics, Mann-Whitney U, and chi-square tests. Results: A total of 76 hospital-based and 149 nonhospital-based patients were recruited with significant differences between settings observed. Nonhospital-based patients showed a markedly higher DRP burden ( Conclusion: This study demonstrates that variations across healthcare settings, compounded by frequent transitions of care, significantly influenced DRP prevalence and characteristics among the highly vulnerable HD patients. Structured support services such as pharmacist-led medication management program play a critical role in mitigating these risks and supporting patients through complex treatment pathways. These findings underscored the importance of addressing both system-level disparities and patient-level challenges, where future research should adopt mixed-method approaches to uncover the contextual drivers of DRPs and guide the development of sustainable, pharmacist-integrated care models that would improve medication safety across diverse dialysis settings.
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