Evidence map›Paper›PMID 41767031›Full record

ArticleCJC pediatric and congenital heart disease2026

Frailty and Cognitive Function After the Age of 40 in Adults With Moderate or Severe Congenital Heart Disease.

Sandra Skogby, Christina Christersson, Joanna Hlebowicz, Zacharias Mandalenakis, Eva Goossens, Adrienne H Kovacs, Liesbet Van Bulck, Koen Luyckx, Philip Moons, Camilla Sandberg and 3 more

Abstract read
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In one paragraph

Article in CJC pediatric and congenital heart disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sandra SkogbyDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Christina ChristerssonDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Joanna HlebowiczDepartment of Cardiology, Skåne University Hospital, Clinical Sciences, Lund University, Lund, Sweden.
Zacharias MandalenakisDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eva GoossensCentre for Research and Innovation in Care, Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Adrienne H KovacsEquilibria Psychological Health, Toronto, Ontario, Canada.
Liesbet Van BulckDepartment of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
Koen LuyckxFaculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.
Philip MoonsDepartment of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
Camilla SandbergDepartment of Community Health and Rehabilitation, Umeå University, Umeå, Sweden.
Bengt JohanssonDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
APPROACH-IS II consortium
International Society for Adult Congenital Heart Disease

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Decades of progress in care and treatment for congenital heart disease (CHD) has gradually shifted the research focus from initial survival to long-term prognosis and the ageing of adults with CHD. Knowledge about the ageing adult with CHD will guide interventions to safeguard the quality of life across the life course. The present study compares the prevalence of frailty and cognitive dysfunction between adults with CHD and a control group. Methods: Using a multicentre design, we compared adults with moderate or complex CHD aged ≥40 years, equally distributed across the age groups 40-49, 50-59, and >60 years, with age- and sex-matched controls. We assessed frailty phenotypes using the Fried method and cognitive dysfunction using the Montreal Cognitive Assessment tool. Results: In total, 156 adults with CHD (56.0 ± 10.4 years, 54.4% male) and 86 controls (55.6 ± 11.2 years, 55.8% male) were included in the study. Adults with CHD and controls did not differ in terms of mean score on the Montreal Cognitive Assessment (mean score 27.1 vs 26.9, Conclusions: Prevalence rates of cognitive dysfunction and frailty were similar between adults with CHD and age-matched controls. As more patients, particularly those with complex heart lesions, reach older ages, the prevalence of cognitive impairment and frailty may change.

Indexed as

ageingcongenitalheart defects

Identifiers

PMID41767031
PMCPMC12946910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.