Evidence map›Paper›PMID 41767007›Full record

ArticleFrontiers in neurology

Loss of embryonic vestibular ganglion neurons in a chick model of congenital vestibular disorders.

Katherine L Phillips, Vanshika Jain, Zoe Shaw, Nina M Bell, Brielle Hentz, Elizabeth B Bogin, Kathleen R Gallagher, Anastas Popratiloff, Kenna D Peusner

Abstract read
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine L PhillipsDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Vanshika JainDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Zoe ShawDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Nina M BellDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Brielle HentzDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Elizabeth B BoginDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Kathleen R GallagherDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Anastas PopratiloffDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Kenna D PeusnerDepartment of Neurology and Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with syndromic, congenital vestibular disorders (CVDs) experience severe challenges to maintain posture and balance throughout life due to malformation of the inner ear into a sac-like structure with missing or truncated semicircular canals. How inner ear malformation affects the remaining vestibular neural circuitry is unknown, although decreased number of vestibular ganglion (VG) neurons is reported in CVD children. Our first step here was to determine whether VG neuron number is reduced before birth using our chick model for CVDs at embryonic day 13 (E13), a stage 2/3 of the way through gestation with hatching at E21. The lab implemented the ARO chick model by

Indexed as

biocytin Alexa fluor labelingconfocal imagingcongenital disordersinner ear pathologysemicircular canals

Identifiers

PMID41767007
PMCPMC12947391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.