ArticleFrontiers in immunology2026
Tissue-invasive CMV disease is associated with poor prognosis during remission induction therapy for autoimmune inflammatory rheumatic diseases.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Remission Induction Therapy in Rheumatic Diseases: Pre-Emptive Treatment of CMV Reactivation?International journal of rheumatic diseases · 2026Article
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4 authors.
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Abstract
Objectives: Cytomegalovirus (CMV) is a notable health concern in immunocompromised individuals and presents as CMV reactivation (CMV infection) or CMV reactivation with tissue invasion (CMV disease). However, few studies have distinguished these CMV patterns during induction therapy for autoimmune inflammatory rheumatic diseases (AIIRDs). This study investigated the clinical characteristics of patients with CMV disease, diagnosed through histopathology, immunohistochemistry, or polymerase chain reaction, during induction therapy for AIIRDs in comparison with those of patients with CMV infection. Methods: This single-center retrospective study included patients with AIIRDs undergoing remission induction therapy with glucocorticoids ≥20 mg/day for ≥4 weeks, hospitalized between 2013 and 2024. Data on clinical characteristics, treatments, and outcomes were collected, and CMV disease, determined by histopathological findings, was compared with CMV infection. Results: Among 82 patients administered AIIRDs and positive for CMV antigenemia, 14 had CMV disease and 68 had CMV infection. CMV disease was associated with lower platelet counts, higher aspartate aminotransferase/alanine transaminase levels, and higher maximum antigenemia. The prevalence of coincident infections (93% vs. 32%) and mortality rate (57% vs. 24%) were higher in patients with CMV disease. Kaplan-Meier analysis showed poorer survival for patients with CMV disease (log-rank test, p=0.027). Receiver operating characteristic analysis identified antigen count (cutoff: 36) as the best predictor of CMV disease. Conclusion: CMV disease during remission induction therapy for AIIRDs is associated with higher antigenemia, more coincident infections, and poorer survival compared with CMV infection. Identifying the risk factors for CMV disease, including antigenemia and coincident infections, can improve patient outcomes.
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