Evidence map›Paper›PMID 41766820›Full record

ArticleFrontiers in immunology2025

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle.

Huldah Sang, Tae Kim, Rakshith Kumar, Jayden McCall, Aloysius Abraham, Tsvetoslav Koynarski, Michelle Zajac, Karim W Abdelsalam, Daniela Hernandez Muguiro, Katherine Bauer and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Huldah SangDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Tae KimDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Rakshith KumarDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Jayden McCallDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Aloysius AbrahamDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Tsvetoslav KoynarskiDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Michelle ZajacDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Karim W AbdelsalamResearch Technology Innovation (RTI) Lab, Brookings, SD, United States.
Daniela Hernandez MuguiroDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Katherine BauerDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Brandon L PlattnerDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.
Waithaka MwangiDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine parainfluenza-3 virus (BPI3V) contributes to Bovine Respiratory Disease Complex, causing severe pneumonia and death in cattle, leading to economic losses. Existing BPI3V commercial vaccines, based on genotype A strains, confer protection against some, but not all, genotype A strains and induce low neutralizing antibody titers against genotypes B and C. This study aimed to develop a live vaccine capable of inducing broad protection against diverse BPI3V strains using an attenuated BPI3V vaccine vector based on a genotype C strain. A rescued recombinant BPI3Vc

Indexed as

Antibodies, NeutralizingAntibodies, ViralAntigens, ViralCattle DiseasesHN ProteinParainfluenza VaccinesParainfluenza Virus 3, BovineRespirovirus InfectionsAnimalsCattleGenetic VectorsVaccinationVaccines, AttenuatedVaccines, SyntheticAntibodies, NeutralizingAntibodies, ViralAntigens, ViralHN ProteinParainfluenza VaccinesVaccines, AttenuatedVaccines, Syntheticantigen surface displaybovine parainfluenza-3 virusbroadly neutralizing antibodyefficacymucosal antibodyrobusttemperature-sensitive vectorvaccine

Identifiers

PMID41766820
PMCPMC12947274

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.