Evidence map›Paper›PMID 41766785›Full record

ReviewUS cardiology2026

The Pathophysiology, Mechanism, Diagnosis, and Management of Pulmonary Arterial Hypertension: A Comprehensive Literature Review.

Apoorva Gangavelli, Ronaldo C Fabiano, Mariam Riad, Gurleen Kaur, Devesh Rai, Mardi Gomberg-Maitland

Abstract readReview
In one paragraph

Review in US cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Apoorva GangavelliDepartment of Medicine, Emory University Atlanta, GA.ORCID https://orcid.org/0000-0002-8467-0866
Ronaldo C FabianoDepartment of Internal Medicine, University of Pittsburgh Medical Center Pittsburgh, PA.ORCID https://orcid.org/0000-0002-8559-3073
Mariam RiadDivision of Cardiovascular Medicine, Department of Medicine, University of South Alabama Mobile, AL.ORCID https://orcid.org/0000-0001-5245-8724
Gurleen KaurDivision of Cardiovascular Medicine, Brigham and Women's Hospital Boston, MA.ORCID https://orcid.org/0000-0002-3693-7722
Devesh RaiDivision of Cardiovascular Medicine, Sands-Constellation Heart Institute, Unity Hospital, Rochester Regional Health Rochester, NY.ORCID https://orcid.org/0000-0003-1287-6440
Mardi Gomberg-MaitlandDivision of Cardiology, School of Medicine & Health Sciences, George Washington University Washington, DC.ORCID https://orcid.org/0000-0003-0482-4560

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension is a rare group of diseases with distinct etiologies affecting all ages, with predominant prevalence in young women. The key common aspect of the disease process is pulmonary arterial remodeling and vasoconstriction, leading to right heart failure. The symptoms most commonly manifest as shortness of breath and progressively worsening exercise intolerance. Early diagnosis, identification of the underlying cause, and targeted treatments aimed at mitigating right heart failure are crucial in management. Although new therapies have emerged recently, it is still a condition with high morbidity and mortality that requires specialized multidisciplinary care. The aim of this study is to review the current literature on key aspects of pulmonary arterial hypertension.

Indexed as

diagnosismanagementpathophysiologyPulmonary arterial hypertension

Identifiers

PMID41766785
PMCPMC12937502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.