Evidence map›Paper›PMID 41766765›Full record

ArticleCase reports in oncological medicine2026

Scleromyxedema Managed With High-Dose Intravenous Immunoglobulin and Bortezomib-Dexamethasone: A Case Report.

Darren Wijaya, Zachary Hanson, Eric K Lau, Mojtaba Akhtari

Abstract read
In one paragraph

Article in Case reports in oncological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Darren WijayaDepartment of Internal Medicine, Loma Linda University Health, Loma Linda, California, USA, lluh.org.ORCID https://orcid.org/0000-0002-6131-579X
Zachary HansonDivision of Medical Oncology and Hematology, Loma Linda University Health, Loma Linda, California, USA, lluh.org.
Eric K LauPalo Alto Medical Foundation, Sutter Health, Palo Alto, California, USA, sutterhealth.org.
Mojtaba AkhtariDivision of Medical Oncology and Hematology, Loma Linda University Health, Loma Linda, California, USA, lluh.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scleromyxedema is a rare, chronic cutaneous mucinosis marked by widespread waxy papules and potential extracutaneous involvement. This case report discusses the management of a 48-year-old female diagnosed with scleromyxedema, who initially partially responded to high-dose intravenous immunoglobulin (HDIVIG) therapy. After partial relapse, she was induced with bortezomib, a proteasome inhibitor, and dexamethasone, achieving significant clinical improvement. Long-term maintenance with IVIG was utilized to prevent recurrence of symptoms. This case highlights the effectiveness of both HDIVIG and bortezomib-dexamethasone dual therapy as viable treatment options for scleromyxedema, emphasizing the importance of maintenance therapy to prevent relapse.

Identifiers

PMID41766765
PMCPMC12943466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.