ArticleAge and ageing2026
Symptoms provide predictive information on daily functioning beyond signs and diseases in middle-aged and older adults, particularly those with multimorbidity.
Article in Age and ageing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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- Erratum issued
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Abstract
backgroundIn people with multimorbidity, traditional, disease-oriented approaches may overlook the impact of symptoms on daily functioning.
objectiveTo explore the assumption that symptoms and signs provide information on functional limitations beyond that of diseases in older adults, specifically those with multimorbidity. SUBJECTS: 4025 participants in the Longitudinal Aging Study Amsterdam (1995-2022).
methodsAnalyses included six symptoms, five signs and eight diseases as exposures and a sum score of six functional limitations as the outcome. Partial Information Decomposition was used to partition the total variability in functional limitations into unique, redundant and synergistic information provided by the exposures in the total sample and in the multimorbidity subgroup. Random forest prediction models were run to examine the added predictive value of symptoms, signs and diseases.
resultsIn the total sample, 59% had multimorbidity. Symptoms, signs and diseases together explained 13.3% of variability in functional limitations. None of the three domains contributed unique information. Synergy accounted for most of the explained variability (signs = 9.2%, symptoms = 34.3%, diseases = 34.3%). In the multimorbidity subgroup, symptoms, signs and diseases together explained 8.7% of variability in functional limitations. Symptoms uniquely contributed 35.5% of their information, while signs and diseases were redundant. Prediction models showed that symptoms provided substantial predictive value beyond diseases alone, with a 110% increase in predictive agreement when symptoms were added to diseases in the multimorbidity subgroup, compared to 58% in the total sample.
conclusionsIn people with multimorbidity, symptoms and signs explain more variability in functional limitations than diseases alone, supporting the need for a symptom-oriented approach in clinical care and research.
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