Evidence map›Paper›PMID 41766529›Full record

ArticleCirculation. Heart failure2026

MUTTON-HF: Rationale and Design of a Study of an Indigenous Food is Medicine Intervention.

Lauren A Eberly, Carmen George, Sharon Sandman, Denee Bex, Karianne Jones, Asia Yazzie, Leah Gray, Larissa Morgan, Ada Tennison, Conor Williams and 13 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06549699 (MUTTON-HF), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06549699 nacompletednot on this map

MUTTON-HF (Medically Used Tailored Traditional Food to Optimize Nutrition) in Heart Failure)

TypeinterventionalSponsorUniversity of PennsylvaniaRan2025 to 2025Enrolled206ConditionsHeart FailureArmsMedically Tailored Meal Program with Traditional Navajo Foods, Usual Care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Lauren A EberlyGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).ORCID 0000-0003-0879-7694
Carmen GeorgeDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA (C.G., S.S., K.J., A.Y., E.F.S., S.S.S.).ORCID 0000-0003-3674-5592
Sharon SandmanDivision of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia (L.A.E., S.S., M.B.).
Denee BexTumbleweed Nutrition, Farmington, NM (D.B.).
Karianne JonesDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA (C.G., S.S., K.J., A.Y., E.F.S., S.S.S.).
Asia YazzieDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA (C.G., S.S., K.J., A.Y., E.F.S., S.S.S.).
Leah GrayGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Larissa MorganGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Ada TennisonGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Conor WilliamsGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Matt ChandraTocabe Inc, Denver, CO (M.C., R. Wickre, B.W.).
Rebecca WickreTocabe Inc, Denver, CO (M.C., R. Wickre, B.W.).
Bennett WickreTocabe Inc, Denver, CO (M.C., R. Wickre, B.W.).
Mackenzie BolasDivision of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia (L.A.E., S.S., M.B.).
Remi WelbelHarvard School of Medicine, Boston, MA (R. Welbel).
Delaney IgnaceHarvard College, Boston, MA (D.I.).
Benjamin FelicianoOffice of Quality, Division of Innovations and Improvement, Indian Health Service Headquarters, Rockville, MD (B.F.).
DezBaa Damon-MalletteGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Erica LindseyGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Paula MoraGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Maricruz MerinoGallup Indian Medical Center, Indian Health Service, NM (L.A.E., L.G., L.M., A.T., C.W., D.B.D.-M., E.L., P.M., M.M.).
Enrique F SchistermanDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA (C.G., S.S., K.J., A.Y., E.F.S., S.S.S.).ORCID 0000-0003-3757-641X
Sonya S ShinDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA (C.G., S.S., K.J., A.Y., E.F.S., S.S.S.).ORCID 0000-0003-3466-9055

Funding

Improving the Quality of Heart Failure Care for American Indian Patients Receiving Care through the Indian Health ServiceK23HL166974 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Lauren A Eberly · 2023 to 2026
$738k
NHLBI NIH HHS K23 HL166974
6 · The paper itself

Abstract

backgroundNutrition insecurity is a major driver of poor cardiovascular health in Indigenous communities. Medically tailored meals may improve heart failure outcomes and quality of life. There is growing momentum among Indigenous communities to reclaim traditional precontact foods to improve cardiovascular health. In this context, utilizing community-based-participatory methods, we designed MUTTON-HF (Medically Utilized Tailored Traditional Foods to Optimize Nutrition in Heart Failure)-an Indigenous culturally and medically tailored meals program that locally sources Native produce and meat and incorporates traditional Diné (Navajo) foods and recipes.

methodsThe MUTTON-HF trial is a 2-center, pragmatic, open-label randomized controlled trial to determine the efficacy and safety of MUTTON-HF among Diné patients with heart failure and hospitalization, or emergency room visit in the last 12 months. Two hundred and four subjects at 2 Indian Health Service sites will be randomized in a 1:1 stratified fashion by sex, age (<65 versus ≥65 years), and left ventricular ejection fraction (<50% versus ≥50%). Study subjects will receive either culturally and medically tailored meals that incorporate traditional Diné recipes and foods or usual dietary advice for 8 weeks. Data analysts will be blinded to group assignment until study completion.

resultsThe primary efficacy end point is the proportion of patients with a hospitalization or emergency room visit (all-cause) within 90 days. Secondary outcomes will include hospitalizations or emergency room visits for heart failure specifically; Kansas City Cardiomyopathy Questionnaire scores for health-related quality of life; measures of food insecurity; Indigenous nourishment; diet quality; financial strain; and clinical biomarkers from study enrollment to 8 weeks.

conclusionsCommunity-based interventions that leverage the protective assets of Indigenous communities are needed to improve cardiovascular health among Native populations. This pragmatic randomized controlled trial will target a rural tribal population and be the first to evaluate the efficacy of an Indigenous food is medicine intervention to improve Indigenous cardiovascular health outcomes for patients with heart failure. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT06549699.

Indexed as

Diet, HealthyHeart FailureNavajo PeopleAgedFemaleFood InsecurityHumansMaleMiddle AgedMulticenter Studies as TopicNutritional StatusPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeAmerican Indian or Alaska Nativecardiomyopathiesfood insecurityheart failurehospitalizationquality of lifesocial determinants of health

Identifiers

PMID41766529
PMCPMC12990973

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.