Letter to the Editor Regarding Kortazar-Zubizarreta et al. 'The Risk of Transmission of Genetic Prion Diseases Is Greater Than 50%'.

Akin Nihat, Tze How Mok, Eric Vallabh Minikel, John Collinge, Simon Mead

Abstract readLetter

In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Akin NihatMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.ORCID https://orcid.org/0000-0003-2892-1402

Tze How MokMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.ORCID https://orcid.org/0000-0002-0141-8412

Eric Vallabh MinikelStanley Center for Psychiatric Research, Broad Institute, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2206-1608

John CollingeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.ORCID https://orcid.org/0000-0003-2220-7566

Simon MeadMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.ORCID https://orcid.org/0000-0002-4326-1468

Funding

Medical Research Council

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Creutzfeldt–Jakob diseasefatal familial insomniagenetic counsellingprion diseasestransmission rate distortion

Identifiers

PMID41766451

DOI10.1111/ene.70543

PMCPMC12951096

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.