Evidence map›Paper›PMID 41766220›Full record

ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2026

Associations of Adiposity With Gut Microbiota Composition Among Adults-Results From a Federated Analysis of Individual Participant Data From Eight European Observational Studies.

Carolina Schwedhelm, Mariona Pinart, Sofia K Forslund-Startceva, Kolade Oluwagbemigun, Andreas Dötsch, Kristina Schlicht, Florian Schwarz, Sofia M Siampani, Demetris Avraam, Maria De Angelis and 18 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Carolina SchwedhelmMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.ORCID 0000-0001-7617-6641
Mariona PinartMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
Sofia K Forslund-StartcevaExperimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Kolade OluwagbemigunDepartment of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Andreas DötschDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut (MRI)-Federal Research Institute of Nutrition and Food, Karlsruhe, Germany.
Kristina SchlichtInstitute of Diabetes and Clinical Metabolic Research, University of Kiel, Kiel, Germany.
Florian SchwarzDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Sofia M SiampaniMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
Demetris AvraamSection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8908-2441
Maria De AngelisDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Jildau BouwmanMicrobiology and Systems Biology Group, Toegepast Natuurwetenschappelijk Onderzoek (TNO), Leiden, the Netherlands.
Patrizia BrigidiMicrobiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Giovanna CaderniNEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
Francesco Maria CalabreseDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Rafael R C CuadratDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Carlotta De FilippoInstitute of Agricultural Biology and Biotechnology, National Research Council, Pisa, Italy.ORCID 0000-0002-2222-6524
Francesca De FilippisDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Danilo ErcoliniDepartment of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
Marco FabbriniMicrobiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Matthias LaudesInstitute of Diabetes and Clinical Metabolic Research, University of Kiel, Kiel, Germany.
Ute NöthlingsDepartment of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Serdar ÖzsezenMicrobiology and Systems Biology Group, Toegepast Natuurwetenschappelijk Onderzoek (TNO), Leiden, the Netherlands.
Itai SharonMigal-Galilee Research Institute, Kiryat Shmona, Israel.ORCID 0000-0003-0705-2316
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Silvia TurroniUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Francesco VitaliInstitute of Agricultural Biology and Biotechnology, National Research Council, Pisa, Italy.ORCID 0000-0001-9125-4337
Tobias PischonMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
Katharina NimptschMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.ORCID 0000-0001-7877-205X

Funding

Bundesministerium für Bildung und Forschung 01EA1906BBundesministerium für Bildung und Forschung 01EA1906FBundesministerium für Bildung und Forschung BMBFBundesministerium für Bildung und Forschung FKZ 01EA1906ABundesministerium für Bildung, Wissenschaft, Forschung und TechnologieBundesministerium für Ernährung und LandwirtschaftEuropean UnionFormas (Sweden) and HDHL-Intimic Era-Net (EarlyFOOD)Fund for Scientific Research (FRS-FNRS, Belgium)Institut National de la Santé et de la Recherche MédicaleJoint Programming Initiative a Healthy Diet for a Healthy Life-Intestinal Microbiomics (JPI HDHL-INTIMIC) Call for Joint Transnational Research Proposals on "Interrelation of the Intestinal Microbiome, Diet and Health" JTC-2017-7Ministerium für Ländliche Entwicklung, Umwelt und Landwirtschaft des Landes Brandenburg DZD Grant 82DZD00302Ministero dell'Istruzione, dell'Università e della RicercaMinistry of Science and Technology (Israel)National Institute of Health Carlos IIINational Research Data Infrastructure for Personal Health Data (NFDI4Health) by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 442326535Research Foundation-Flanders (FWO, Belgium)the Netherlands Organization for Health Research and Development (ZonMw, the Netherlands)
6 · The paper itself

Abstract

Gut microbiota may contribute to the adiposity-associated disease risk, but human studies reported inconsistent associations of adiposity with gut microbiota composition. We examined associations of body mass index (BMI) with alpha diversity and relative microbial abundance at the phylum and genus taxonomic levels (based on 16S rRNA amplicon sequencing or metagenomics) among 7415 adults from eight European observational studies in a joint federated analysis of harmonized data using DataSHIELD. Higher BMI (per 5 kg/m

Indexed as

AdiposityGastrointestinal MicrobiomeObesityAdultBody Mass IndexEuropeFemaleHumansMaleMiddle AgedObservational Studies as TopicRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbody mass indexfederated analysisfiber intakegut microbiotaobservational studies

Identifiers

PMID41766220
PMCPMC13371411

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.