ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Clinical significance of neutrophil chemokines in intestinal tissue and related receptor expression in peripheral blood in neonatal necrotizing enterocolitis].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo analyze changes in neutrophil infiltration and chemokines in intestinal tissue from neonates with necrotizing enterocolitis (NEC), and to assess the expression of related receptors in peripheral blood, in order to explore their significance in NEC.
methodsClinical data, peripheral blood, and intestinal tissue from neonates with NEC and intestinal atresia who underwent surgery at the Third Affiliated Hospital of Zhengzhou University from June 2022 to September 2023 were prospectively collected and classified into an NEC group and an intestinal atresia group. Pathology results, chemokine levels in intestinal tissue, and neutrophil chemokine receptors in peripheral blood were compared between the two groups.
resultsIn the NEC group, marked accumulation of neutrophils was observed in intestinal tissue. Compared with the intestinal atresia group, intestinal tissue concentrations of CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL8, and interleukin-1 receptor antagonist were higher (all
conclusionsIn NEC, chemokine concentrations in intestinal tissue are broadly elevated, and peripheral blood leukocytes express neutrophil chemokine receptors, which together may promote the migration and infiltration of neutrophils from peripheral blood into intestinal tissue.
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