Evidence map›Paper›PMID 41766121›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

In Vivo Microendoscopy in the Near-Infrared II Window.

Zhisheng Wu, Danyang Xu, Zideng Dai, Xinyuan Wang, Wayne Jason Li, Sixin Xu, Xun Zhang, Yuanhua Liu, Puxian Xiong, Hanze Yu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhisheng WuDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Danyang XuDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Zideng DaiDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Xinyuan WangDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Wayne Jason LiDepartment of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Sixin XuDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Xun ZhangDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Yuanhua LiuDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Puxian XiongDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Hanze YuDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Wentao YeDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Liangqiong QuDepartment of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong SAR, China.
Yongye LiangDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Hongjie DaiMaterials Innovation Institute for Life Sciences and Energy (MILES), The University of Hong Kong-SIRI, Shenzhen, China.
Feifei WangDepartment of Electrical and Computer Engineering, School of Biomedical Engineering, The University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-7687-3412

Funding

Early Career Scheme 27204623General Research Fund 17212424National Natural Science Foundation of China T2522030NSFC/RGC Collaborative Research Scheme CRS_HKU703/25Start-up funding from Materials Innovation Institute for Life Sciences and Energy (MILES), HKU-SIRI in Shenzhen
6 · The paper itself

Abstract

Non-invasive fluorescence endoscopy of deep biological tissues beyond the mucosa, or trans-intestinal imaging in live mammals with high spatiotemporal resolution, remains challenging due to light scattering. Here, we developed a near-infrared II (NIR-II) microendoscopy with imaging wavelength extended to 1700 nm, enabling deep intestinal imaging beyond the mucosa and transrectal imaging at sub-10-µm resolution without any invasive surgery. It facilitated real-time visualization of the relative motion of vascular networks across different layers of the mouse rectum. Featuring a specially designed large field of view, the NIR-II microendoscopy enabled non-invasive transrectal imaging of the entire lumbar lymph node for the first time, revealing abnormal lymphatic drainage in tumor-bearing mice. In vivo longitudinal imaging of healthy mice and colitis-bearing mice mapped distinct fluorescence patterns in rectal vasculature and lumbar lymph nodes, enabling observation of lesions in acute colitis at the initial stage, and opening new possibilities for studying the interaction between the intestinal microenvironment and lymphatic systems.

Indexed as

EndoscopyInfrared RaysAnimalsColitisLymph NodesMiceSpectroscopy, Near-InfraredcolitisIn vivo imaginglymph nodemicroendoscopynear‐infrared II imaging

Identifiers

PMID41766121
PMCPMC13114502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.