SynthesisJournal of the Egyptian National Cancer Institute2026
Efficacy of scrambler therapy in chemotherapy-induced peripheral neuropathy: a systematic review of randomized controlled trials.
Synthesis in Journal of the Egyptian National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundChemotherapy-induced peripheral neuropathy (CIPN) treatment is challenging due to limited and often unsatisfactory therapy options. Scrambler therapy (ST) is gaining interest as treatment option with promising initial results. However, further evaluation is needed to confirm its effectiveness. PURPOSE: The purpose of this review was to evaluate the efficacy of scrambler therapy in the management of chemotherapy-induced peripheral neuropathy.
methodsThis systematic review followed the PRISMA guidelines and the Joanna Briggs Institute (JBI) methodology; however, the protocol was not prospectively registered in the PROSPERO database. Electronic databases (CINAHL, Scopus, Web of Science, ScienceDirect, and PubMed) were searched from January 2014 to August 2024. Only English-language randomized controlled trials were eligible. Two reviewers independently screened studies, extracted data, and appraised methodological quality using JBI critical appraisal tools.
resultsTwo independent randomized controlled trials, reported across three publications, met the inclusion criteria. The sample size ranged between 35 and 50 participants, and the mean age ranged between 59 and 61 years. The overall quality assessment ranged between low to moderate risk of bias. The reviewed studies demonstrated varying results regarding the efficacy of ST in managing CIPN. Two studies suggest that ST may reduce CIPN symptoms and improve quality of life, although these effects did not reach statistical significance (p > 0.05). However, one study’s lack of significant benefit highlights treatment variability and limitations.
conclusionScrambler therapy does not yet meet statistical criteria for a successful treatment CIPN. Further RCTs with large samples, blinding, and extended follow-up is needed to validate ST effectiveness.
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