Evidence map›Paper›PMID 41766015›Full record

ArticleLasers in medical science2026

Photobiomodulation therapy reduces diabetic periodontal damage through modulation of macrophage metabolism and functions.

Pawuziya Abulizi, Hao Dong, Aimin Cui, Haonan Zou, Yuezhang Sun, Lulinxiao Nie, Bomiao Cui, Shimeng Xiao, Yi Ding, Wai Keung Leung and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pawuziya AbuliziState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Hao DongState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Aimin CuiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Haonan ZouState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yuezhang SunState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Lulinxiao NieState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Bomiao CuiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Shimeng XiaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yi DingState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wai Keung LeungPeriodontology and Implant Dentistry Division, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Qi WangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. wqinno8751@gmail.com.

Funding

National Natural Science Foundation of China 82470985Natural Science Foundation of Sichuan Province 2024NSFSC0548
6 · The paper itself

Abstract

Diabetes mellitus disrupts macrophage function and immune homoeostasis, thereby increasing susceptibility toward periodontitis. PBMT shows emerging potential in oral rehabilitation. However, it remains underexplored for targeting diabetes-associated periodontal complications. This study aimed to investigate the biomodulatory effects of PBMT on hyperglycaemia-associated macrophage dysfunction, metabolic disorders, and periodontal tissue impairment. Immortalized bone marrow-derived macrophages undergoing glucose transition and streptozotocin-induced diabetic mice received PBMT (980 nm, 3 J/cm²), insulin, or combined therapy. Pharmacological inhibition using specific inhibitors targeting FOXO1, AKT, and ERK was employed to elucidate signaling mechanisms. Cellular functions were assessed through Transwell migration, phagocytosis, and senescence-associated β-galactosidase staining. Metabolic parameters were evaluated via western blotting, ATP/LDH assays, and immunostaining. Tissue morphology was analyzed using micro-CT and H&E staining. PBMT enhanced macrophage phagocytosis, migration, and anti-inflammatory phenotype. The combined PBMT-insulin therapy demonstrated superior efficacy in restoring periodontal architecture compared to monotherapy. Mechanistically, PBMT attenuated FOXO1 hyperactivation primarily through MEK/ERK signaling. PBMT effectively counteracted hyperglycemia-induced metabolic dysregulation, restored macrophage function and phenotype, and mitigated subsequent periodontal tissue damage. The MEK/ERK/FOXO1 signalling pathway may represent a novel mechanism underlying the benefits of PBMT.

Indexed as

Diabetes Mellitus, ExperimentalLow-Level Light TherapyMacrophagesPeriodontitisAnimalsForkhead Box Protein O1InsulinMaleMiceMice, Inbred C57BLPhagocytosisSignal TransductionForkhead Box Protein O1Foxo1 protein, mouseInsulinDiabetes mellitusGlucose metabolismPeriodontal tissuePhotobiomodulation therapy

Identifiers

PMID41766015
PMCPMC12950657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.