Evidence map›Paper›PMID 41765928›Full record

ArticleTranslational psychiatry2026

Decreased Broca-left supplementary motor area connectivity underlying auditory verbal hallucination: A resting-state NIRS study.

Zetao Huang, Yingding Ma, Jiuju Wang, Yanping Song, Jiaxin Zhang, Ziyu Ye, Dafang Ouyang, Daijun Ke, De Cao, Wentian Dong

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Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zetao HuangPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Yingding MaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Jiuju WangPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Yanping SongPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Jiaxin ZhangKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beihang University, Beijing, China.
Ziyu YePeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Dafang OuyangPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Daijun KePeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
De CaoDatong Sixth People's Hospital, Datong, Shanxi Province, 037000, China.
Wentian DongPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. puh60134@bjmu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82571709
6 · The paper itself

Abstract

backgroundDespite decades of research, the underlying mechanism of auditory verbal hallucinations (AVH), a core symptom of schizophrenia, remain unclear. Previous studies have tried to capture the neural activity during AVH episodes, whereas trait features of AVH have been less investigated. To address this gap, we employed functional Near-Infrared Spectroscopy (fNIRS) to investigate the neuroimaging patterns in healthy controls (HCs), patients with schizophrenia with a history of AVH (AVHh+) and those without a history of AVH history (AVHh-). We hypothesized that significant differences of functional connectivity (FC) changes would be observed in AVHh+.

methodWe recruited 23 AVHh+, 16 AVHh-, and 17 matched HCs. Participants underwent an 8-minute resting-state fNIRS scanning. Data processing and analysis were conducted by the NirSpark software (HuiChuang, China) package and R Studio.

resultCompared to the AVHh-, the AVHh+ showed significantly lower FC between the Broca's area and the left supplementary motor area (SMA).

conclusionThe hypoconnectivity of Broca-left SMA circuit might serve as a trait-like marker of vulnerability to AVH.

Indexed as

Broca AreaHallucinationsMotor CortexSchizophreniaAdultBrain MappingCase-Control StudiesFemaleHumansMaleNeural PathwaysSpectroscopy, Near-InfraredYoung Adult

Identifiers

PMID41765928
PMCPMC12963401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.