Observational studyLasers in surgery and medicine2026
Clinical and Histopathological Assessment of the Field of Cancerization in Human Skin Before and After Treatment With a 1927-nm Thulium Fractional Laser.
Observational study in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundField cancerization is a major concern in photodamaged skin due to its risk of progression to squamous cell carcinoma. The 1927-nm thulium laser has emerged as a promising therapy, but its isolated effects on this condition remain underexplored.
objectiveTo evaluate clinical and histopathological changes in field cancerization treated with the 1927-nm thulium laser.
methodsIt was a prospective, observational, and interventional clinical study. Twenty-three patients (age average of 61.3 years), phototype I-III, with facial photodamage and multiple actinic keratosis underwent 4 monthly sessions of thulium laser, followed by a 3-month evaluation. Outcomes included lesion counts and a photoaging scale at each session, along with comprehensive histological analysis of pre- and post-treatment biopsies from 20 patients.
resultsThere was a significant reduction in AK count (p < 0.001) and photoaging parameters (p < 0.001). Histologically, we observed improvement in vertical extension of keratinocyte atypia (p = 0.046), increased dermal thickness (p = 0.012), and fibroplasia (p < 0.001). No severe adverse effects occurred.
conclusionThe 1927-nm thulium laser is a safe, well-tolerated and has promising results as a field-directed therapy for actinic keratosis, promoting both clinical and histopathological improvement.
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