Evidence map›Paper›PMID 41765470›Full record

ReviewJournal of clinical and experimental hematopathology : JCEH2026

Clinicopathological features of gastric Langerhans cell histiocytosis and a literature review.

Xue Chen, Yunjin Wu, Xueli Wang, Muye Yang, Xiaoxiang Gao, Suxia Zhang, Huihui Sun, Yunhui Zhang, Hongmei Yi, Yu Zeng

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hematopathology : JCEH, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xue ChenDepartment of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Yunjin WuDepartment of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Xueli WangDepartment of Pathology, Children's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Muye YangDepartment of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Xiaoxiang GaoDepartment of Orthopedics, Naval Medical Research Institute: Chinese People's Liberation Army Naval Medical Center, Shanghai, China.
Suxia ZhangDepartment of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Huihui SunDepartment of Gastroenterology, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Yunhui ZhangKey Lab Laboratory of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
Hongmei YiDepartment of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu ZengDepartment of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective This study aims to review the clinicopathological features, molecular profiles, and clinical behavior of gastric LCH to increase diagnostic accuracy and improve the understanding of its prognosis. Methods We analyzed five cases of gastric LCH and integrated clinical, endoscopic, and pathological data. Diagnoses were confirmed via immunohistochemistry (S-100, CD1a, and Langerin). BRAF-V600E mutation status was assessed by PCR in three patients. A literature review of 17 additional cases was included for a comprehensive analysis. Results Patients presented with nonspecific symptoms such as abdominal pain. Endoscopy predominantly revealed solitary polyps (<1 cm) or mucosal thickening, primarily in the gastric body. Histology revealed characteristic neoplastic cells with grooved nuclei and eosinophilic cytoplasm, accompanied by eosinophil infiltration. All patients were positive for S-100, CD1a, and Langerin. The BRAF-V600E mutation was detected in all three tested cases. Systemic involvement occurred in two patients. Treatment ranged from surveillance to chemotherapy. All patients were alive after follow-up (8-62 months), with most patients showing no progression. Conclusion Gastric LCH typically presents as a small, solitary polyp. S-100, CD1a, and Langerin positivity was observed by immunohistochemistry. The high frequency of BRAF-V600E mutations provides a diagnostic adjunct and potential therapeutic target. Gastric LCH patients have a good prognosis and long overall survival when the cancer is a localized lesion. However, systemic involvement may necessitate chemotherapy, and regular follow-up is recommended.

Indexed as

Histiocytosis, Langerhans-CellStomach DiseasesAdultAntigens, CDAntigens, CD1FemaleHumansImmunohistochemistryLectins, C-TypeMaleMannose-Binding LectinsMiddle AgedMutationProto-Oncogene Proteins B-rafAntigens, CDAntigens, CD1BRAF protein, humanCD1a antigenCD207 protein, humanLectins, C-TypeMannose-Binding LectinsProto-Oncogene Proteins B-rafBRAF-V600E mutationdiagnosisgastricimmune phenotypeLangerhans cell histiocytosis

Identifiers

PMID41765470
PMCPMC13160645

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.