ArticleNeuropharmacology2026
Functional interaction between orexin/CRF and orexin/dynorphin transmission in the infralimbic cortex modulates the stress-induced reinstatement of alcohol-seeking behavior in male and female Wistar rats.
Article in Neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Stress contributes to the chronic relapsing nature of alcohol use disorder (AUD), given its ability to elicit craving and precipitate relapse, even after long periods of self-imposed abstinence. Although not thoroughly understood, anatomical, pharmacological, and behavioral data suggest orexin (OX), corticotropin-releasing factor (CRF), and dynorphin (DYN) interact, particularly in the infralimbic cortex (IL). Functional interactions between these three systems in the IL may be critical for the etiology and pervasiveness of compulsive alcohol seeking in dependent subjects, rendering them vulnerable to relapse. Male and female Wistar rats were trained to self-administer 10% alcohol for 3 weeks and then made dependent via chronic intermittent alcohol vapor exposure for 6 weeks. Following extinction training (12 sessions), rats received an intra-IL microinfusion of the OX
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