Evidence map›Paper›PMID 41764988›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

HIV-1 integrase resistance in the context of antiretroviral therapy in paediatric patients ‒ Northeast Brazil.

Aldicléya Lima Luz, Élcio Leal, Kledoaldo Lima, Mikhael Morais de Souza, Michelle Lima de Carvalho Silva, Mayra Moura Lima, Paloma Gomes Tavares Sette, Yasmim Leandra Moura de Almeida, Heloísa Ramos Lacerda de Melo

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Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aldicléya Lima LuzUniversidade Federal do Maranhão, Faculdade de Medicina, Imperatriz, MA, Brazil; Programa de Pós-Graduação em Medicina Tropical, Recife, PE, Brazil.
Élcio LealUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Diversidade Viral, Belém, PA, Brazil.
Kledoaldo LimaFaculdade Pernambucana de Saúde (FPS), Recife, PE, Brazil; Universidade Federal de Pernambuco, Hospital das Clínicas, Cidade Universitária, Recife, PE, Brazil. Electronic address: kledoaldo@fps.edu.br.
Mikhael Morais de SouzaFaculdade Pernambucana de Saúde (FPS), Recife, PE, Brazil.
Michelle Lima de Carvalho SilvaFaculdade Pernambucana de Saúde (FPS), Recife, PE, Brazil.
Mayra Moura LimaFaculdade Pernambucana de Saúde (FPS), Recife, PE, Brazil.
Paloma Gomes Tavares SetteFaculdade Pernambucana de Saúde (FPS), Recife, PE, Brazil.
Yasmim Leandra Moura de AlmeidaFaculdade Pernambucana de Saúde (FPS), Recife, PE, Brazil.
Heloísa Ramos Lacerda de MeloPrograma de Pós-Graduação em Medicina Tropical, Recife, PE, Brazil; Universidade de Pernambuco, Faculdade de Ciências Médicas, Departamento de Medicina Clínica, Recife, PE, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAntiretroviral drug resistance poses a challenge to therapy efficacy. Although Integrase Strand Transfer Inhibitors (INSTIs) have a high genetic barrier to resistance, few studies in Brazil have focused on INSTI resistance. This study aimed to assess HIV mutations associated with INSTI resistance in vertically infected children in Maranhão and Pernambuco, Brazil.

methodsWe conducted a retrospective analysis of antiretroviral resistance profiles in paediatric patients with virological failure receiving care through the Brazilian Unified Health System. Data on viral load, CD4+/CD8+ T-cell counts, and medication dispensing were obtained from Ministry of Health databases (SISGENO, SISCEL, and SICLOM). HIV-1 integrase sequences were analysed. Phylogenetic analysis (IQ-TREE) was used to identify subtypes and recombinants. Resistance-associated mutations were determined using the Stanford HIV Drug Resistance Database.

resultsThirty-one paediatric patients (median age = 12-years) were included. Mean CD4+ count was 999 cells/mm³, and median viral load was 19,235 copies/mL. Subtype B and INSTI resistance mutations were detected in 74.5 % and 64.5 % of patients, respectively. High resistance rates to raltegravir (70.9 %) were observed, highlighting the importance of genotypic monitoring.

conclusionA high frequency of INSTI resistance-associated mutations was identified, indicating the need for continued surveillance in this population.

Indexed as

Drug Resistance, ViralHIV-1HIV InfectionsHIV IntegraseHIV Integrase InhibitorsAdolescentBrazilCD4 Lymphocyte CountChildChild, PreschoolFemaleGenotypeHumansMaleMutationPhylogenyHIV IntegraseHIV Integrase InhibitorsAnti-Retroviral agentsHIV-1IntegraseIntegrase inhibitorsMolecular epidemiology

Identifiers

PMID41764988
PMCPMC12966703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.