ArticleJournal of musculoskeletal & neuronal interactions2026
Mechanical Load-Capacity Models for Bone in Youth - Analysis of Risk Signatures.
Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesto explore associations between mechanical load, expressed by structural (appendicular lean soft tissue index, ALSTI; ALST/trunk fat mass, TrFM); and functional lean mass (handgrip strength, HGS; HGS/body mass) with the mechanical capacity of bone, represented by whole-body bone mineral density less head (WBLH BMD) and arms/legs BMD imbalance.
methodsWe analysed cross-sectional NHANES data from 5,424 adolescents (10-19 years, both sexes) collected between 2011 and 2020. ALST, TrFM and BMD were determined using whole-body dual-energy X-ray absorptiometry, and HGS was assessed with a dynamometer. All variables were standardised by sex and age group (Z-scores), with Z ≤ -1 indicating low or at-risk values.
resultsThe odds of low WBLH BMD were higher in participants with low ALSTI (girls: OR= 3.9; boys: OR=4.5, p < 0.001) or low HGS (girls: OR=3.1; boys: OR=4.5, p < 0.001). Boys with low HGS/body mass had 1.8 times higher odds of low arms/legs BMD (p = 0.012), while girls with low HGS/body mass had 4.0 times higher odds (p < 0.001).
conclusionsBoth structural and functional lean mass deficits are associated with reduced WBLH BMD and arms/legs BMD imbalance in adolescents. These findings reinforce the importance of lean soft tissue in bone health monitoring.
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41764755PMC12952506What OpenQuestion holds
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