Evidence map›Paper›PMID 41764749›Full record

ArticleJournal of musculoskeletal & neuronal interactions2026

Donald W Golden, Jason P Oliemans, Aera J M Ladell, Kalindra D Walls, Eric C Bennett, Spencer J Skaper, Michael J Asmussen, Ranita H K Manocha, Jared R Fletcher

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Donald W GoldenDepartment of Health and Physical Education, Mount Royal University, Calgary, AB Canada.
Jason P OliemansDepartment of Health and Physical Education, Mount Royal University, Calgary, AB Canada.
Aera J M LadellDepartment of Biology, Mount Royal University, Calgary, AB Canada.
Kalindra D WallsDepartment of Health and Physical Education, Mount Royal University, Calgary, AB Canada.
Eric C BennettDepartment of Health and Physical Education, Mount Royal University, Calgary, AB Canada.
Spencer J SkaperDepartment of Health and Physical Education, Mount Royal University, Calgary, AB Canada.
Michael J AsmussenDepartment of Kinesiology, Faculty of Health Sciences and Human Service. Vancouver Island University. Nanaimo, BC Canada.
Ranita H K ManochaCumming School of Medicine, University of Calgary. Calgary, AB Canada.
Jared R FletcherDepartment of Health and Physical Education, Mount Royal University, Calgary, AB Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the force-length relationship, muscle thickness (MT), pennation angle (PA) and echo-intensity (EI) of the medial gastrocnemius (MG) in HSD/hEDS compared to healthy controls.

methodsThe maximal MG force-length relationship was determined throughout ankle passive ROM in 11 individuals with HSD/hEDS and 11 healthy age- and sex-matched controls. MG fascicle length (FL), MT, PA and EI were measured using ultrasonography. MG force was calculated from plantarflexion moments and MG FL. Sarcomere lengths (SL) were estimated from changes in FL and assuming an optimal SL of 2.64 μm at optimal fascicle length.

resultsHSD/hEDS were 36% weaker across the ankle ROM (p = 0.047). Optimal FL was significantly shorter in HSD/hEDS (34.8±8.1 mm) compared to controls (43.6±6.9 mm; p = 0.013). A shallower descending limb of the force-length relationship was seen in HSD/hEDS (p <0.001). MT, PA, and EI were similar between groups (p > 0.05).

conclusionHSD/hEDS were weaker at all measured fascicle lengths, despite similar muscle architecture (MT, PA) and quality (EI) suggesting that reduced neuromuscular activation may contribute to muscle weakness in this population. Rehabilitation interventions should consider addressing joint-angle specific strength deficits in HSD/hEDS.

Indexed as

Ehlers-Danlos SyndromeJoint InstabilityMuscle, SkeletalMuscle StrengthAdultAnkle JointFemaleHumansMaleRange of Motion, ArticularUltrasonographyYoung AdultEhlers-Danlos SyndromeJoint InstabilityMuscle StrengthMuscle Weakness

Identifiers

PMID41764749
PMCPMC12952507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.