ArticleIntensive care medicine experimental2026
The P0.1 maneuver as an alternative method for assessing the validity of esophageal pressure measurements during assisted ventilation: an exploratory analysis.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05203536 (ICEBERG STUDY. Respiratory Mechanics Assessment During Assisted Mechanical Ventilation), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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ICEBERG STUDY. Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
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7 authors.
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Abstract
backgroundTranspulmonary pressure, calculated as the difference between airway pressure (Paw) and esophageal pressure (Pes), is an important monitoring parameter during assisted mechanical ventilation, provided Pes is measured via a correctly placed and filled esophageal pressure probe. The reference method to verify Pes accuracy in spontaneously breathing patients requires calculating the ratio of changes in Pes and Paw (ΔPes/ΔPaw) during an inspiratory effort against an occluded airway. We hypothesized that the P0.1 maneuver, a brief and repeatable test, could provide an alternative means to assess ΔPes/ΔPaw during assisted mechanical ventilation.
methodsWe performed an exploratory secondary analysis of data from a multicenter prospective observational study (ICEBERG study; NCT05203536). In 35 patients receiving assisted mechanical ventilation, ΔPes/ΔPaw obtained during P0.1 maneuvers (Ratio
resultsAmong 25 patients with 65 evaluable measurements, Ratio
conclusionsOur exploratory analysis suggests that the P0.1 maneuver may support semi-continuous screening of esophageal pressure signal validity during assisted ventilation. While abnormal P0.1 values should prompt confirmatory occlusion testing, values within the expected range may help rule out major measurement errors. These findings provide a rationale for prospective validation studies including different ventilator types.
trial registrationclinicaltrials.gov, NCT05203536. Registered 24. January 2022-Retrospectively registered, https://classic. CLINICALTRIALS: gov/ct2/show/NCT05203536.
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