ArticleDocumenta ophthalmologica. Advances in ophthalmology2026
The area under the waveform as an alternative measure of the photopic negative response.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo explore how the photopic negative response (PhNR), measured as an area defined by the ERG waveform can be used as complementary or an alternative measure to the traditionally measured PhNR amplitude.
methodsA retrospective chart review and data analysis of light-adapted 3.0 ERG records in patients and normal subjects patients aged 18 and older undergoing routine ERG testing was conducted. A new measure was analyzed: area defined by the PhNR curve. It was obtained in two ways: as an area under the ERG waveform (AUW) and an area above the ERG waveform (AAW) with starting points defined by the b-wave peak and time windows ranging from 5 to 45 ms in duration. A linear regression was conducted between PhNR1 amplitude (trough before i-wave), PhNR2 amplitude (trough after i-wave), PhNR AUW, and PhNR AAW. Furthermore, a prediction analysis based on AUW/AAW was conducted where the strongest correlated measures were used to predict the PhNR2 amplitude.
resultsThe ERG recordings of 70 patients/135 eyes (52F/18 M, average age: 49.2 ± 15.3 years) and six healthy subjects (1F/5 M, age between 22 and 58) were included in this study. 26 patients had well-defined PhNR2 troughs and were used for prediction analysis. There was good correlation between PhNR1 and PhNR2 amplitudes (r
conclusionsDetermining and using AAW/AUW for PhNR2 prediction could be a valuable method in cases where the PhNR2 peak is not well defined.
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