ArticleEye and vision (London, England)2026
Short-term effects of atropine on the retina and choroid in young adults.
Article in Eye and vision (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multimodal Retinal Structural and Functional Tests Identify Local and Layer-Related Alterations in Early Type 2 Diabetes.Investigative ophthalmology & visual science · 2026Article
- Myopia Prevalence, Ocular Metrics and Visual Activity in United States Optometry Students.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2026Article
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Authors and funding
2 authors.
Funding
Abstract
backgroundLow concentration atropine is widely prescribed to slow myopia progression in children, yet its short-term retinal and choroidal effects remain incompletely understood. This study aimed to evaluate short-term effects of a range of low atropine concentrations on axial length, retinal and choroidal thickness, and microvasculature.
methodsIn this double-masked, randomized study, twenty healthy adults received a single instillation of placebo, 0.01%, 0.025%, 0.05%, or 0.1% atropine in the right eye across five separate sessions. Retinal and choroidal thickness in the central 1.0 mm diameter and 1.0-3.0 mm annulus, perfusion density in the superficial and deep vascular complex and choriocapillaris in the central 1.0 mm and 1.0-2.5 mm annulus, foveal avascular zone and axial length were assessed at baseline and 1 h and 24 h after instillation.
resultsParticipant mean age was 25.5 ± 3.4 years and mean refraction was - 1.9 ± 2.2 D. No significant changes in retinal or choroidal thickness or axial length were observed for any concentration or time point (P > 0.05). The superficial vascular plexus perfusion density in the 1.0-2.5 mm annulus showed significant decrease (P = 0.02) with time after atropine instillation, but not with concentration (P > 0.05); post hoc analysis showed significant decrease from baseline at 1 h (P = 0.03) compared to 24 h (P = 0.28).
conclusionThese findings indicate that a single instillation of 0.01%-0.1% atropine does not alter axial length or retinal or choroidal thickness over 24 h, but may transiently affect superficial retinal perfusion in a time-dependent manner. Characterizing these short-term effects is important for a better understanding of the physiological responses to atropine in clinical and research settings.
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