Evidence map›Paper›PMID 41764549›Full record

ArticleGenome biology2026

Multi-context seeds enable fast and high-accuracy read mapping.

Ivan Tolstoganov, Marcel Martin, Nicolas Buchin, Kristoffer Sahlin

Abstract read
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Sassy: fuzzy searching DNA sequences using SIMD.Bioinformatics (Oxford, England) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ivan TolstoganovDepartment of Mathematics, Science for Life Laboratory, Stockholm University, 10691, Stockholm, Sweden.
Marcel MartinDepartment of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University, Box 1031, 17121, Solna, Sweden.
Nicolas BuchinDepartment of Mathematics, Science for Life Laboratory, Stockholm University, 10691, Stockholm, Sweden.
Kristoffer SahlinDepartment of Mathematics, Science for Life Laboratory, Stockholm University, 10691, Stockholm, Sweden. ksahlin@math.su.se.

Funding

Knut och Alice Wallenbergs Stiftelse 2020.0239Vetenskapsrådet 2021-04000
6 · The paper itself

Abstract

A key step in sequence similarity search is to identify shared seeds between a query and a reference sequence. A well-known tradeoff is that longer seeds offer fast searches but reduce sensitivity in variable regions. We introduce multi-context seeds (MCS), which allow the storage of seeds with different lengths in the same index structure, thus retaining the advantages of both short and long seeds. We demonstrate the applicability of MCS by implementing them in strobealign. Strobealign with MCS substantially improves accuracy compared to the previous version with little cost in runtime and no memory overhead.

Indexed as

Sequence Analysis, DNASoftwareAlgorithmsSequence AlignmentIlluminaK-mersRead mappingSeedsStrobemers

Identifiers

PMID41764549
PMCPMC13059148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.