Evidence map›Paper›PMID 41764506›Full record

ArticleJournal of nanobiotechnology2026

Glucose oxidase-mineralized scaffolds with multiple bioactivities for accelerated diabetic bone regeneration.

Yancheng Zhu, Xiaohao Liu, Zhuyun Cai, Yunshan Fan, Zhi Zhou, Guoli Deng, Feng Chen, Shaohua Li, Shisheng He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yancheng Zhu *Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Nanjing Medical University, Shanghai, 200072, P.R. China.
Xiaohao Liu *Department of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P.R. China.
Zhuyun Cai *Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, P.R. China.
Yunshan FanDepartment of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Nanjing Medical University, Shanghai, 200072, P.R. China.
Zhi ZhouDepartment of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Nanjing Medical University, Shanghai, 200072, P.R. China.
Guoli DengDepartment of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P.R. China.
Feng ChenShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 201102, P.R. China. chen_feng@fudan.edu.cn.
Shaohua LiDepartment of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Nanjing Medical University, Shanghai, 200072, P.R. China. doctorli77@163.com.
Shisheng HeDepartment of Orthopaedics, Shanghai Tenth People's Hospital, School of Medicine, Nanjing Medical University, Shanghai, 200072, P.R. China. tjhss7418@tongji.edu.cn.

Funding

National Key R&D Program of China 2022YFE0123500National Natural Science Foundation of China 52572298National Natural Science Foundation of China 82372442Science and Technology Bureau of Suzhou City SZKJXM202318Shanghai Science and Technology Committee BJKJ2024001
6 · The paper itself

Abstract

Diabetic bone defects pose a significant clinical challenge due to impaired healing under hyperglycemia. However, no effective therapy is available to treat diabetic bone defect in clinic. This study engineers a biomimetic 3D-printed scaffold for diabetic bone regeneration by integrating glucose oxidase-mineralized amorphous calcium phosphate (GOx@ACP) nanoparticles into a gelatin methacryloyl (GelMA) hydrogel. Biomineralization encapsulates GOx within ACP, enhancing enzymatic stability and enabling glucose-responsive degradation. The scaffold exerts dual therapeutic actions consuming glucose to alleviate hyperglycemia while generating trace H₂O₂ to promote angiogenesis, alongside releasing osteogenic ions (Ca²⁺/PO₄³⁻) upon ACP degradation. The scaffold's sustained degradation profile (with 61.02% mass retention after 28 days) ensures matched release kinetics of ions and enzymes, thereby synergistically promoting bone regeneration. In vitro, the scaffold significantly enhances bone marrow stromal cell proliferation, osteogenic differentiation with upregulated OPN/OCN/Runx2/Col-Ⅰ expression, and endothelial tubulogenesis. In diabetic rat cranial defects, the implantation significantly accelerated bone regeneration, with the bone volume (BV/TV) reaching approximately 52% by the 12th week. This enzyme-mineralized platform demonstrates promising potential for diabetic bone tissue engineering.

Indexed as

Bone RegenerationDiabetes Mellitus, ExperimentalGlucose OxidaseTissue ScaffoldsAnimalsCalcium PhosphatesCell DifferentiationCell ProliferationGelatinHydrogelsMaleMesenchymal Stem CellsMethacrylatesNanoparticlesOsteogenesisRatscalcium phosphateCalcium PhosphatesGelatingelatin methacryloylGlucose OxidaseHydrogelsMethacrylatesBiomineralizationBone regenerationCalcium phosphateDiabetesGlucose oxidase

Identifiers

PMID41764506
PMCPMC13059438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.