ArticleBMC ophthalmology2026
Comparison of optic nerve head and macular perfusion changes before and after the development of COVID-19.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19 is known to induce systemic endothelial inflammation and microvascular dysfunction, with reported implications for various tissues, including ocular structures. Optical coherence tomography angiography (OCTA) offers a non-invasive and high-resolution method to visualize and quantify retinal microcirculatory networks. While prior research has investigated ocular microvascular changes in COVID-19 patients, studies comparing these alterations in the same individuals before and after infection are limited.
methodsAmong individuals who had baseline OCTA at their previous admission to our clinic, 20 patients who later contracted and recovered from COVID-19 were included in the study. OCTA images were obtained using the AngioVue optical coherence tomography angiography system, with split-spectrum amplitude decorrelation angiography images. After resolution of COVID-19, OCTA was performed again in these patients, and the results were compared with the previous foveal avascular zone (FAZ) and vessel densities (VD) findings.
resultsAfter disease resolution, the optic nerve head vessel density (ONH-VD) was found to be statistically significantly decreased in all areas except the superonasal area, while the radial peripapillary capillary vessel density (RPC-VD) was found to be statistically significantly decreased in all areas, except inside the disc and superonasal and temporal areas. The superficial capillary plexus vessel density (SCP-VD) was found to be significantly decreased in the superior hemi, superior and nasal areas, and the deep capillary plexus vessel density (DCP-VD) significantly decreased in the whole image, parafovea, and inferior hemi and inferior and nasal areas.
conclusionsAfter resolution of COVID-19, the ONH-VD and RPC-VD decreased generally, and in the macular region, the SCP-VD and DCP-VD decreased in certain areas. These results may be important in understanding the effects of COVID-19 on systemic vascular circulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.