Evidence map›Paper›PMID 41764241›Full record

ArticleNature communications2026

Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination.

Sha Luo, Ruolin Qiao, Hailiang Zha, Leyi Yu, Xiaoling Shan, Shuchan Li, Zifan Yang, Aoyu Ma, Yaxin Cheng, Yao-Feng Zhao and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sha Luo *Biomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Ruolin Qiao *Biomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Hailiang Zha *Biomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Leyi Yu *Biomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Xiaoling ShanBiomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Shuchan LiBiomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Zifan YangBiomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Aoyu MaBiomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China.
Yaxin ChengState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China.
Yao-Feng ZhaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0003-4499-8610
Xuefei ZhangBiomedical Pioneering Innovation Center (BIOPIC), School of Life Science, Peking University, Beijing, China. Xuefei_zhang10@pku.edu.cn.ORCID http://orcid.org/0000-0002-1873-6679

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32270930
6 · The paper itself

Abstract

Activation-induced cytidine deaminase (AID)-initiated immunoglobulin heavy chain (Igh) class switch recombination (CSR) replaces donor Cμ constant region exons (C

Indexed as

ChromatinImmunoglobulin Class SwitchingImmunoglobulin Heavy ChainsAICDA (Activation-Induced Cytidine Deaminase)AnimalsB-LymphocytesCytidine DeaminaseExonsMiceRecombination, GeneticAICDA (Activation-Induced Cytidine Deaminase)ChromatinCytidine DeaminaseImmunoglobulin Heavy Chains

Identifiers

PMID41764241
PMCPMC13066422

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.