ArticleAnnals of biomedical engineering2026
Endoluminal Catheter Pulsed Field Ablation for the Treatment of Atherosclerotic Vascular Disease.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
purposeAtherosclerotic vascular disease remains a leading cause of morbidity and mortality worldwide. Current treatments such as angioplasty, stenting, and atherectomy are invasive and limited by restenosis, thrombosis, and incomplete long-term efficacy. Pulsed field ablation (PFA), a nonthermal electroporation-based modality, has demonstrated safety in other cardiovascular applications, but it has not been applied for the treatment of endoluminal vascular diseases. We investigated whether pulsed electric fields could be delivered within the coronary artery and if PFA could selectively ablate the cellular components of atherosclerotic plaques.
methodsAn endoluminal bipolar PFA probe was fabricated using a balloon catheter with flexible electrodes and evaluated in potato and ex vivo porcine hearts. The electrical conductivities of human atherosclerotic plaques were derived from previous impedance measurements for patient-specific multi-tissue and single-cell electroporation modeling. PFA was then evaluated for selective decellularization within an electrical conductivity-matched 3D fibrotic atherosclerosis tissue mimic using high concentrations of human macrophages and aggregated oxidized low-density lipoproteins, encapsulated within a collagen matrix.
resultsEndoluminal probe positioning and high-voltage pulsed electric field delivery feasibility was established within the porcine left coronary arteries, with susequent potato lesions experiments demonstrating maximum ablations (6.99 cm
conclusionsThis study provides practical demonstration of PFA for the treatment of atherosclerotic vascular disease. By combining experimental validation with computational modeling, we establish proof-of-concept that endoluminal PFA can selectively ablate diseased cells while preserving extracellular architecture, laying the groundwork for future translational development of this therapy.
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