Trial reportThe American journal of clinical nutrition2026
Infant hyperglycemic excursions by saliva 1,5-anhydroglucitol varied by weight status, rapid weight gain, and mode of feeding: an exploratory secondary analysis.
Trial report in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05012930 (Effects of Complementary Feeding on Infant Growth and Gut Health), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Complementary Feeding on Infant Growth and Gut Health
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundEarly infant feeding and weight gain can impact the development of chronic diseases. 1,5 anhydroglucitol (1,5-AG) is a measure of hyperglycemic excursions (HEs) and decreases during HEs due to increased urinary excretion.
objectivesWe hypothesized that HEs as measured by 1,5-AG are associated with infant rapid weight gain (RWG).
methodsInfants from the Maternal and Infant Nutrition Trial, a randomized controlled feeding trial, participated in this exploratory secondary analysis. Saliva from 127 infants aged 5 mo was collected before the introduction of complementary foods. Saliva 1,5-AG concentration was measured using liquid chromatography-mass spectrometry and log transformed for statistical analyses. Demographic, anthropometric, and feeding mode [exclusively human milk-fed (EHMF), exclusively formula fed (EFF), and mixed fed (MF)] data were collected. RWG was classified as an increase in the weight-for-age z-score (WAZ) >0.67 from birth to 5 mo.
resultsSaliva 1,5-AG concentrations were negatively correlated with an increase of WAZ at 5 mo (r = -0.238, P = 0.01). EHMF and MF infants had significantly greater log transformed 1,5-AG μg/dl values (-0.252 ± 0.639 and 0.332 ± 0.912, respectively) than EFF infants (-1.754 ± 0.705, P = 0.001). Birth weight, but not sex, age, or maternal body mass index, was positively associated with WAZ changes. Saliva 1,5-AG concentrations remained inversely associated with the change in WAZ values in adjusted regression models when controlling for birth weight (β: -0.214; 95% confidence interval: -0.38, -0.05), but not when mode of feeding was included. The odds ratio for 1,5-AG (0.50; 95% confidence interval: 0.28, 0.90) was also significantly associated with RWG using logistic regression controlling for birth weight.
conclusionsThese results suggest that human milk-fed infants have fewer HEs than EFF infants. Lower saliva 1,5-AG concentrations were associated with an increase in WAZ and RWG. Additional analyses are needed to evaluate the underlying drivers of HEs and their association with infant growth and health. This study was registered at clinicaltrials.gov as NCT05012930.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.