Evidence map›Paper›PMID 41763216›Full record

ArticleCell reports. Medicine2026

A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorder.

Xin Li, Banglian Hu, Chujun Wu, Ziwei Wang, Hanzheng Fan, Xiaoyan Guan, Sulan Xie, Dadian Chen, Xiaohua Huang, Hao Sun and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xin LiXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Banglian HuXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Chujun WuDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Ziwei WangXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Hanzheng FanXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Xiaoyan GuanXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Sulan XieXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Dadian ChenXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Xiaohua HuangBasic Medical Sciences, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Hao SunXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Yanfang LiXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Xian ZhangXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Guojun BuDivision of Life Science and State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Zhanxiang WangDepartment of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.
Yun-Wu ZhangXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: yunzhang@xmu.edu.cn.
Li ZhongXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: zhongli@xmu.edu.cn.
Zaiqiang ZhangDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Electronic address: ttyy0142011@126.com.
Honghua ZhengXiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: honghua@xmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The I794T hotspot mutation in the colony-stimulating factor 1 receptor (CSF1R) gene is associated with primary microgliopathy manifesting as leukoencephalopathy. In this study, we identify three Chinese probands harboring the CSF1R p.I794T variant and characterize their clinical and neuroimaging profiles. To elucidate disease mechanisms and explore therapeutic avenues, we generate a Csf1r

Indexed as

LeukoencephalopathiesMicrogliaMutationReceptors, Granulocyte-Macrophage Colony-Stimulating FactorAnimalsDisease Models, AnimalFemaleHumansMaleMiceReceptor, Macrophage Colony-Stimulating FactorCSF1R protein, humanCsf1r protein, mouseReceptor, Macrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating FactorCSF1RCSF1R-RDleukoencephalopathymicrogliamicroglia replacement

Identifiers

PMID41763216
PMCPMC13006430

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.