Evidence map›Paper›PMID 41762891›Full record

ArticleRedox biology2026

NMRK2-YAP-NADK axis preserves redox protection against myocardial ischemia/reperfusion injury.

Chao Zhang, Jie Wang, Jing Chi, Su-Ting Liu, Xiao-Wen Meng, Lin-Gui Li, Shunli Dong, Hui Cao, Xing-Gen Zhou, Yang Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chao ZhangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.
Jie WangDepartment of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
Jing ChiDepartment of Radiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
Su-Ting LiuDepartment of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
Xiao-Wen MengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.
Lin-Gui LiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.
Shunli DongDepartment of Pharmacy, The Affiliated Children's Hospital of Soochow University, China.
Hui CaoDepartment of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
Xing-Gen ZhouDepartment of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
Yang ZhangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.
Hai-Yan SunDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.
Pei-Pei KangDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.
Ke PengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China. Electronic address: pengke0422@163.com.
Fu-Hai JiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China. Electronic address: jifuhaisuda@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial oxidative stress during myocardial ischemia/reperfusion (I/R) injury precipitates cell death and heart failure, for which translatable redox therapies remain scarce. Here, we show that nicotinamide riboside kinase 2 (NMRK2) is rapidly upregulated after reperfusion and exerts redox protection by a previously unrecognized mechanism. We established myocardial I/R injury in mice and hypoxia/reoxygenation (H/R) injury in cardiomyocytes. By elevating NADPH, restoring NAD

Indexed as

Adaptor Proteins, Signal TransducingMyocardial Reperfusion InjuryPhosphotransferases (Alcohol Group Acceptor)AnimalsCell Cycle ProteinsHumansMiceMyocytes, CardiacOxidation-ReductionOxidative StressSignal TransductionTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsPhosphotransferases (Alcohol Group Acceptor)Transcription FactorsYap1 protein, mouseYAP-Signaling ProteinsCardiomyocytesMyocardial ischemia-reperfusion injuryNADKNMRK2Redox protectionYAP

Identifiers

PMID41762891
PMCPMC12962100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.