ArticleUltrasonics sonochemistry2026
Ultrasound-assisted deep eutectic solvent extraction of ginseng folium polysaccharides: Extraction mechanism, process optimization, structural characterization, and in vitro biological activity.
Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Optimization of Crude Polysaccharide Extraction and Purification from the Black Outer Layer of theFoods (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to develop a green, efficient ultrasound-assisted (UA) deep eutectic solvent (DES) extraction method for ginseng folium polysaccharides (GFPs). This approach overcomes the low yields and long extraction period of conventional techniques. Seventeen DES systems were screened, identifying choline chloride-lactic acid (ChCl-La, 1:2) as the optimal solvent. Key parameters were optimized using Plackett-Burman design followed by Box-Behnken response surface methodology, yielding optimal conditions of 30 min ultrasonic time, a liquid solid ratio of 25 mL/g, ultrasonic power of 299.16 W, and DES water content of 30.82%. The effects of three extraction methods, namely hot water extraction (HWE), UA extraction (UAE), and UA-DES, on polysaccharide characteristics were compared. Monosaccharide analysis showed that HWE-GFP was rich in glucose (Glc, 16.15%) and glucuronic acid (GlcA, 45.23%), whereas UAE and UA-DES were enriched in galactose (30.79% and 37.78%, respectively) and arabinose (21.69% and 29.80%, respectively). UA-DES-GFP had a significantly lower molecular weight (361.70 kDa) than UAE-GFP (1497.40 kDa) or HWE-GFP (3304.35 kDa). Fourier-transform infrared spectroscopy revealed no major differences in functional groups among the three GFPs. Molecular dynamics simulations of the ChCl-La system elucidated the extraction mechanism, highlighting favorable electrostatic potential energy (-20.14 eV) and hydrogen bond length (2.204 Å) interactions with GFP. In vitro bioassays showed that HWE-GFP had stronger antioxidant activity (61.97%), whereas UA-DES-GFP exhibited superior α-glucosidase inhibition (59.54%). These differences likely stem from variations in the GlcA/Glc ratio. Overall, this study provides a high-yield, green extraction strategy for GFP, along with mechanistic insights and technical guidance for utilizing ginseng leaf polysaccharides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.