Evidence map›Paper›PMID 41762709›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

PVN

Jiang Bian, Xiao-Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao-Xia Xiang, Na Tian, Li-Juan Chen, Ming-Wei Ma and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiang BianNeuropsychiatry Research Institute, Basic School of Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Xiao-Long WangDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Li YinDepartment of Anesthesiology, Panzhihua Central Hospital, Panzhihua, China.
Wei WeiDepartment of Radiology, Henan Provincial People's Hospital & State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Zhengzhou University, Zhengzhou, Henan, China.
Xue LiDepartment of Neurology, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Yao GeDepartment of Radiology, Henan Provincial People's Hospital & State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Zhengzhou University, Zhengzhou, Henan, China.
Zhao-Xia XiangNeuropsychiatry Research Institute, Basic School of Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Na TianDepartment of Radiology, Henan Provincial People's Hospital & State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Zhengzhou University, Zhengzhou, Henan, China.
Li-Juan ChenDepartment of Radiology, Henan Provincial People's Hospital & State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Zhengzhou University, Zhengzhou, Henan, China.
Ming-Wei MaDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Xia ZhangNeuropsychiatry Research Institute, Basic School of Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Xu JingDepartment of Radiology, Henan Provincial People's Hospital & State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0009-0009-4260-0374
Mei-Yun WangDepartment of Radiology, Henan Provincial People's Hospital & State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Zhengzhou University, Zhengzhou, Henan, China.
Xu-Feng XuNeuropsychiatry Research Institute, Basic School of Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

Funding

1.3.5 Talent Excellence Development Project-West China Hospital of Sichuan University ZYGD23034Health Commission of Sichuan Province Medical Science and Technology Program 24QNMP019Major Basic research program of Shandong Province Natural Science Foundation ZR2019ZD035National Natural Science Foundation of China 32000788National Natural Science Foundation of China 81830035National Natural Science Foundation of China 82090033National Natural Science Foundation of China 82571728Shandong Province Natural Science Foundation ZR2019BC097Shandong Province Natural Science Foundation ZR2024MH063Sichuan Province Natural Science Foundation 2026NSFSC1634STI2030-Major Projects 2021ZD0203000STI2030-Major Projects 2021ZD0203002
6 · The paper itself

Abstract

Migraine is a prevalent and debilitating neurological disorder with poorly understood neural mechanisms. Here, we characterize a hypothalamic-trigeminal pathway involved in the regulation of migraine-like allodynia. Using a combination of monosynaptic circuit, fiber photometry-based calcium imaging, and behavioral assays in a nitroglycerin (NTG)-induced murine model, we observed hyperactivity in corticotropin-releasing factor (CRF)-expressing neurons within the hypothalamic paraventricular nucleus (PVN). Activation or inhibition of PVN

Indexed as

HyperalgesiaMigraine DisordersNeuronsParaventricular Hypothalamic NucleusReceptors, Corticotropin-Releasing HormoneTrigeminal Nucleus, SpinalAnimalsCorticotropin-Releasing HormoneDisease Models, AnimalMaleMiceCorticotropin-Releasing HormoneCRF receptor type 2Receptors, Corticotropin-Releasing Hormonechronic migrainecorticotropin‐releasing factorthe hypothalamic paraventricular nucleusthe spinal trigeminal nucleus caudalis

Identifiers

PMID41762709
PMCPMC13205600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.