ArticleFolia microbiologica2026
Plasmid-mediated resistance in Neisseria gonorrhoeae clinical strains from South Poland, 2014-2021.
Article in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Antimicrobial resistance (AMR) of Neisseria gonorrhoeae is a global public health concern. This resistance may result from the presence of plasmid-encoded proteins or mutations within chromosomal genes. Tetracyclines are used in post-exposure prophylaxis (PEP) of sexually transmitted infections (STIs), especially in high-risk populations. In this study, the susceptibility of 116 N. gonorrhoeae strains to penicillin and tetracycline was evaluated. Plasmid-mediated resistance was determined using both phenotypic and molecular methods. Among the analysed strains, 15 (12.9%) and 47 (40.5%) were resistant to penicillin and tetracycline, respectively. Plasmid-mediated resistance to penicillin and/or tetracycline was confirmed in 27 (23.3%) strains. The blaTEM gene of the African type was detected in all PPNG strains, while the tetM gene of either the Dutch or American variant was identified in HLTR strains. A statistically significant correlation between the presence of blaTEM and tetM plasmid-encoded resistance genes suggests a potential cooccurrence of resistance mechanisms within the gonococcal population. The strains with plasmid-mediated resistance were classified into 14 NG-MAST sequence types (STs), with ST11461 and ST14769 being the most common.
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