ArticleEuropean journal of applied physiology2026
Impact of ionic imbalances on rat cardiomyocyte function in pulmonary arterial hypertension: insights from energy dispersive X-ray spectroscopy and scanning electron microscopy analysis.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Calcium, sodium and potassium are essential for the contractile function of cardiomyocytes. In pulmonary arterial hypertension (PAH), intracellular calcium dynamics are impaired, affecting contractility and leading to heart failure. Energy-dispersive X-ray spectroscopy associated with scanning electron microscopy (EDS-SEM) technique can be useful for mapping the distribution of these minerals in cardiac tissue. This study aimed to investigate chronic ionic imbalances in the cardiac tissue of a monocrotaline (MCT) induced PAH model, using EDS-SEM, and to evaluate the impact of these imbalances on the contractile function of isolated RV myocytes. Twenty-eight Wistar rats were assigned to Control and PAH groups, with PAH induced by MCT. Right ventricular (RV) function was assessed by echocardiography at day 24. On day 25, cardiac tissue was analyzed by EDS-SEM to quantify electrolytes and by Western blotting, and RV myocyte contractility was measured. Student's t-test was performed to compare the groups. Animals with PAH showed reduced final weight, increased cardiac and RV weight, and reduced RV systolic function compared to controls. EDS-SEM analysis revealed lower Ca and Na density in cardiac tissue of PAH animals. The expression of Ca
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