ArticleAnimal models and experimental medicine2026
Isovolumic relaxation strain imaging is an accurate and sensitive approach for detection of active diastolic dysfunction: A preclinical study.
Article in Animal models and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundCurrently, there is no imaging-based method for directly detecting active diastolic dysfunction. This study aimed to evaluate the efficacy of isovolumic relaxation strain imaging (IVSI) in assessing active diastolic dysfunction in preclinical settings.
methodsActive diastolic function was assessed in C57BL/6J mice subjected to transverse aortic constriction (TAC) or a sham operation using daily conventional echocardiography and strain imaging over a 14-day period, with follow-ups at weeks 4 and 8. A modified approach was developed to accurately identify the isovolumic relaxation time (IVRT) using an apical three-chamber view.
resultsThe novel imaging protocol successfully identified IVRT in each mouse. TAC mice exhibited significant alterations in E/A and E/E' ratios from day 12 to 14, while the average strain rate detected by IVSI showed a significant decrease from day 4. After 8 weeks, TAC mice developed severe heart failure with reduced ejection fraction, but conventional echocardiography failed to detect diastolic dysfunction.
conclusionIVSI continued to indicate obvious diastolic alterations. Together, these data suggested that IVSI is an effective imaging-based method for direct detection of active diastolic dysfunction with high accuracy and sensitivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.