Evidence map›Paper›PMID 41762179›Full record

ArticleJACC. Asia2026

Comparison of Flow Ratio Derived From IVUS With CAG in Complex Lesions: Correlation With FFR.

Rende Xu, Zhe Wang, Congcong Pan, Wei Gao, Leilei Ma, Yizhe Wu, Zhangwei Chen, Yang Lu, Yong Dong, Wei Yu and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322355 (Comparison of Flow Ratio Derived From Intravascular Ultrasound With Coronary Angiography in Stable Coronary Artery Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322355 completednot on this map

Comparison of Flow Ratio Derived From Intravascular Ultrasound With Coronary Angiography in Stable Coronary Artery Disease: Correlation With Fractional Flow Reserve

TypeobservationalSponsorShanghai Zhongshan HospitalRan2018 to 2023Enrolled250ConditionsCoronary Artery DiseaseArmsCoronary angiography, Fractional Flow Reserve measurement, Intravascular ultrasound
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rende XuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhe WangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Geriatric Center, Shanghai, China.
Congcong PanDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Wei GaoDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Leilei MaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Yizhe WuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhangwei ChenDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Yang LuDepartment of Cardiology, Shanghai 7th People's Hospital, Shanghai, China.
Yong DongDepartment of Cardiology, Zhengzhou 7th People's Hospital, Zhengzhou, China.
Wei YuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address: heronet@sjtu.edu.cn.
Shengxian TuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Chenguang LiDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: li.chenguang@zs-hospital.sh.cn.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate evaluation of coronary artery disease is critical for guiding treatment decisions, particularly in complex coronary lesions. Fractional flow reserve (FFR) remains the gold standard for assessing lesion-specific ischemia but is invasive and requires pharmacological hyperemia. Noninvasive alternatives, such as quantitative flow ratio (QFR) from coronary angiography and ultrasonic flow ratio (UFR) from intravascular ultrasound (IVUS), offer promising diagnostic approaches.

objectivesThis study aimed to compare the diagnostic performance of UFR and QFR against FFR in assessing complex coronary lesions.

methodsThis retrospective multicenter study included 217 patients (220 vessels) who underwent IVUS and FFR. UFR was derived from IVUS imaging, and QFR was calculated using coronary angiography data. Correlation, agreement, and diagnostic metrics (sensitivity, specificity) were analyzed, with receiver operating characteristic curves assessing accuracy.

resultsUFR demonstrated stronger correlation with FFR (r = 0.79; 95% CI: 0.74-0.84; P < 0.001) compared with QFR (r = 0.68; 95% CI: 0.60-0.74; P < 0.001). UFR also showed better diagnostic performance, with an area under the receiver operating characteristic curve of 0.91 (95% CI: 0.86-0.94) compared with QFR's 0.86 (95% CI: 0.81-0.90). In complex lesions (diffuse, bifurcation, calcified), UFR consistently outperformed QFR, particularly in bifurcation and lesions heavily calcified, where QFR accuracy dropped significantly (72.5% vs 86.8%, P = 0.001).

conclusionsIn this retrospective hypothesis-generating study, UFR showed numerically higher diagnostic accuracy than QFR in complex coronary lesions. These findings suggest UFR may have potential as a complementary tool for functional assessment, but definitive conclusions about superiority require validation in larger prospective studies. (Comparison of UFR With QFR in Stable Coronary Artery Disease; NCT06322355).

Indexed as

complex coronary lesionquantitative flow ratioultrasonic flow ratio

Identifiers

PMID41762179
PMCPMC13153880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.