ArticleEndocrinology, diabetes & metabolism2026
Relationship Between Body Composition With Carotid Intima Media Thickness in Young Adults: Tehran Lipid and Glucose Study.
Article in Endocrinology, diabetes & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBody composition, particularly the interplay between skeletal muscle mass and adiposity, has gained attention for its potential impact on cardiovascular health. This study aimed to examine the relationship between body composition and carotid artery intima-media thickness (cIMT) as an indicator of early atherosclerosis.
methodsThis cross-sectional study was conducted in the Tehran Lipid and Glucose Study (TLGS) cohort, focusing on young adults. Anthropometric measurements, laboratory tests and cIMT assessments were performed. Body composition was assessed using bioelectrical impedance analysis (BIA). The association between skeletal muscle mass index (SMMI) and skeletal muscle mass (SMM) with cIMT was analysed using linear and logistic regression models, adjusted for relevant covariates.
resultsA total of 795 participants (361 women, 434 men) were included in the study. Higher SMMI and SMM quartiles were associated with increased cIMT and a higher risk of high cIMT (above the 75th percentile). For instance, in the age-adjusted model, the highest quartile (Q4) of SMMI was associated with high cIMT with an OR of 1.80 (95% CI, 1.02-3.20) in men and an OR of 2.17 (95% CI, 1.14-4.13) in women. While these associations were significant after adjustment for age, further adjustment for cardiovascular risk factors attenuated some associations, particularly for SMMI quartiles. However, SMMI and SMM as continuous variables remained positively and significantly associated with cIMT in both sexes (e.g., for fully-adjusted continuous SMMI: β = 0.010 in men, β = 0.013 in women), indicating a persistent linear relationship independent of major confounders.
conclusionIn young adults, higher skeletal muscle mass was independently associated with greater cIMT, suggesting it may signal early vascular changes rather than protection, especially when coinciding with higher adiposity. This underscores the need to assess overall body composition and for future longitudinal studies to determine causality.
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