Evidence map›Paper›PMID 41761893›Full record

ArticleChemical biology & drug design2026

Design, Synthesis, and Evaluation of Bis-Chalcones and Bis-Flavones as Selective COX-2 Inhibitors.

Rui Pereira, Marisa Freitas, Alberto N Araújo, Vera L M Silva, Eduarda Fernandes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui PereiraLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Marisa FreitasLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Alberto N AraújoLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Vera L M SilvaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0003-0938-5085
Eduarda FernandesLAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0001-6424-0976

Funding

Fundação para a Ciência e a Tecnologia UI/BD/151269/2021Fundação para a Ciência e a Tecnologia UID/50006
6 · The paper itself

Abstract

Over the past two decades, the search for safe and effective COX-2 inhibitors has spurred extensive research on flavonoids. Within this context, synthetic flavonoid dimers have emerged as a promising subclass with potential anti-inflammatory activity. To investigate whether dimerization enhances their potency and selectivity, novel A-fused bis-chalcones and A-fused bis-flavones were synthesized and evaluated for their inhibitory activity against isolated human COX-1 and COX-2 enzymes, as well as their effects on prostaglandin E

Indexed as

ChalconesCyclooxygenase 2Cyclooxygenase 2 InhibitorsDrug DesignFlavonesCyclooxygenase 1DimerizationDinoprostoneHumansStructure-Activity RelationshipChalconesCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsDinoprostoneFlavonesbis‐chalconesbis‐flavonescyclooxygenase‐2enzyme inhibitionin vitro evaluationsynthesiswhole‐blood

Identifiers

PMID41761893
PMCPMC12949472

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.