ArticleChemistryOpen2026
Phytochemical Profiling of the Halophyte Artemisia fukudo Makino and Its In Vitro Effects on Androgen-Related Pathways Associated With Benign Prostatic Hyperplasia and Alopecia.
Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Jaceidin Inhibits Proliferation and Promotes Apoptosis in Oral Squamous Cell Carcinoma Cells by Regulating Survivin and AKT/ERK Signaling Pathways.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Artemisia fukudo Makino is a biennial halophyte from the Asteraceae family, known for its tolerance to high-salinity soils. Based on the excellent activity of A. fukudo extract in regulating the 5α-reductase type 2 (5αR2) enzyme, this study aimed to investigate the phytochemical properties and pharmaceutical potential of A. fukudo for treating benign prostatic hyperplasia (BPH) and alopecia. Eight compounds including sesquiterpenes (1-4), coumarin (5), and flavonoids (6-8) were isolated from 90% MeOH fraction of A. fukudo, and their structures were determined using NMR and MS experiments. Among the isolated compounds, compounds 5-7 were detected in HPLC-DAD, and contents of compounds 5-8 were successfully quantified using ESI-MS. It was found that 90% MeOH fraction of A. fukudo contained scopoletin (5), jaceosidin (6), eupatilin (7), and jaceidin (8) at the concentration of 1.44, 35.71, 6.44, and 11.19 mg/g, respectively. Compound 8 effectively inhibited the expressions of BPH-related proteins, AR, PCNA, PSA, and 5αR2 in LNCaP and RWPE-1 cells. Meanwhile, compound 7 exhibited potent activity in regulating Wnt/β-catenin signaling and induced the expression of VEGF and IGF-1 in HaCaT and HUVECs. These findings suggest that A. fukudo and its bioactive constituents represent novel natural substances for treatment or improvement of BPH and alopecia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.