Evidence map›Paper›PMID 41761757›Full record

Observational studyJournal of clinical hypertension (Greenwich, Conn.)2026

Revealing Sex Differences in Hypertensive Urgency Management: Insights From a Tertiary Hospital.

Grethzel Prado, Carlos Bea, Elena Martínez, Rubén Gómez, David Ruíz, Celia Prades, Alicia Marco, Inma Sauri, María José Forner, Enrique Rodilla and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. In Hypertensive Urgency With Volume Overload-Intravenous Loop Diuretic may be Indicated.Journal of clinical hypertension (Greenwich, Conn.) · 2026
    Article
  2. Article
  3. Hypertensive Urgency: Which Patient Will be Fine in a Quiet Room?Journal of clinical hypertension (Greenwich, Conn.) · 2026
    Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Grethzel PradoPolytechnic University Hospital La Fe, Valencia, Spain.
Carlos BeaHypertension Unit, Clinical University Hospital, Valencia, Spain.
Elena MartínezPolytechnic University Hospital La Fe, Valencia, Spain.
Rubén GómezPolytechnic University Hospital La Fe, Valencia, Spain.
David RuízHypertension Unit, Clinical University Hospital, Valencia, Spain.
Celia PradesHypertension Unit, Clinical University Hospital, Valencia, Spain.
Alicia MarcoHypertension Unit, Clinical University Hospital, Valencia, Spain.
Inma SauriResearch Institute of the Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.
María José FornerHypertension Unit, Clinical University Hospital, Valencia, Spain.
Enrique RodillaDepartment of Internal Medicine, Hypertension and Vascular Risk Unit, Hospital De Sagunto, Foundation For the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
Josep RedonResearch Institute of the Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.
Fernando MartínezHypertension Unit, Clinical University Hospital, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex differences in hypertensive urgencies (HUs) remain poorly characterized in emergency department (ED) settings. We conducted a retrospective observational study of adult ED visits for hypertensive urgency at a tertiary hospital in Spain between 2018 and 2022, excluding hypertensive emergencies. Sex differences in ED-based incidence, clinical presentation, blood pressure (BP) trajectories, acute management, and ED outcomes were assessed using multivariable regression models with correction for multiple testing. Among 2769 patients with HUs, women accounted for most cases and had a higher ED-based incidence than men. Women were older and more frequently reported headache or dizziness, whereas men more often presented with dyspnea or chest pain. Systolic BP trajectories during ED stay were similar between sexes, while diastolic BP remained higher in women. No clinically relevant sex differences were observed in acute pharmacological management after multiple-testing correction. Marked BP reductions frequently occurred during ED stay without pharmacologic intervention and were comparable between sexes. Overall, hypertensive urgencies showed relevant sex differences in incidence and clinical presentation, while blood pressure often declined even in the absence of acute pharmacological treatment, with limited differences in acute management or short-term BP response between women and men.

Indexed as

Antihypertensive AgentsEmergency Service, HospitalHypertensionAgedBlood PressureBlood Pressure DeterminationEmergency Room VisitsFemaleHumansHypertensive CrisisIncidenceMaleMiddle AgedRetrospective StudiesSex FactorsSpainAntihypertensive Agentsemergency servicehospitalhypertensionhypertensive urgenciesretrospective studiessex factors

Identifiers

PMID41761757
PMCPMC12949392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.