Evidence map›Paper›PMID 41761622›Full record

ArticleDiabetes/metabolism research and reviews2026

Impact of Adverse Metabolic Factors on the Burden of Chronic Kidney Disease in the Chinese Population ≥ 20 Years Old, 1990-2019.

Jiali Huang, Yiwei He, Fan Yang

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Article in Diabetes/metabolism research and reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Jiali HuangDepartment of Endocrine and Metabolism, Geriatric Diseases Institute of Chengdu, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, China.
Yiwei HeDepartment of Nephrology, Xiangya Hospital Zhuzhou, Central South University, Zhuzhou, China.
Fan YangDepartment of Endocrine and Metabolism, Geriatric Diseases Institute of Chengdu, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo quantify temporal trends in chronic kidney disease (CKD) burden attributable to adverse metabolic risk factors among Chinese adults aged ≥ 20 years during 1990-2019. MATERIALS AND

methodsWe used Global Burden of Disease Study 2019 (GBD 2019) estimates for China to assess five CKD causes (CKD due to type 1 diabetes, type 2 diabetes, hypertension, glomerulonephritis, and other/unspecified causes) and three metabolic risks (high systolic blood pressure (SBP), high body mass index (BMI), and high fasting plasma glucose (HFPG)). Outcomes were deaths and disability-adjusted life years (DALYs) (numbers and rates per 100,000), stratified by sex and 13 age groups. Joinpoint regression was used to estimate annual percent change (APC) and average annual percent change (AAPC) in rates from 1990 to 2019.

resultsIn 2019, the mortality rate for CKD attributable to these metabolic risks was 6.87 per 100,000, and total attributable DALYs were 4201 (thousand). Hypertensive nephropathy had the largest attributable burden (mortality 2.5/100,000; DALY rate 59.2/100,000), followed by CKD due to type 2 diabetes. From 1990 to 2019, the overall attributable CKD mortality rate increased (AAPC = 0.55%) while the DALY rate decreased slightly (AAPC = -0.27%). High SBP remained the leading contributor to attributable burden in 2019, whereas high BMI showed the fastest increase in attributable mortality burden over time. Attributable burden increased steeply with age and was higher in males than in females.

conclusionsHigh SBP remains a major driver of CKD burden in China, but the rapidly rising high-BMI-attributable burden highlights the need for integrated prevention focused on blood pressure control and obesity prevention, particularly among older adults and men.

Indexed as

Cost of IllnessDiabetes Mellitus, Type 2HypertensionRenal Insufficiency, ChronicAdultAgedBody Mass IndexChinaDisability-Adjusted Life YearsEast Asian PeopleFemaleFollow-Up StudiesGlobal Burden of DiseaseHumansMaleMiddle AgedChinachronic kidney diseasedisease burdenglobal burden of diseasemetabolic risk factors

Identifiers

PMID41761622
PMCPMC12949367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.