Evidence map›Paper›PMID 41761616›Full record

ReviewPlant communications2026

Editing and synthetic engineering of chloroplast genomes.

Jinqiu Fu, Jiang Zhang

Abstract readReview
In one paragraph

Review in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jinqiu FuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
Jiang ZhangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China; School of Life Sciences, Hubei Hongshan Laboratory, Hubei University, Wuhan 430062, China. Electronic address: zhangjiang@caas.cn.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Chloroplasts are central to photosynthesis and metabolic biosynthesis in plants and algae, offering immense potential for synthetic biology. This review highlights recent advances in chloroplast genome minimization, high-efficiency genome editing, and metabolic pathway redesign aimed at optimizing chloroplast function. We first summarize strategies for relocating chloroplast-encoded genes to the nuclear genome, thereby facilitating chloroplast genome streamlining while maintaining gene expression. We then discuss cutting-edge tools for precise chloroplast genome editing, including gene knockout, knockin, base substitution, and multiplex modifications. Finally, we explore the dynamic regulation of chloroplast energy metabolism and the redesign of core metabolic pathways to enable de novo biosynthesis of high-value compounds, enhancing production efficiency and enabling crop trait improvement. Together, these integrated approaches pave the way for next-generation chloroplast engineering with broad implications for biotechnology and agriculture.

Indexed as

ChloroplastsGene EditingGenome, ChloroplastSynthetic BiologyMetabolic EngineeringPhotosynthesischloroplast genome minimizationcrop improvementgenome editingmetabolic engineeringsynthetic biology

Identifiers

PMID41761616
PMCPMC12983252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.