ArticleMedical physics2026
Influence of radiotherapy dose rate on gold nanoparticle-induced radiosensitization from high dose-rate brachytherapy and external beam therapy.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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7 authors.
Funding
Abstract
backgroundAssociated normal tissue toxicity from current radiotherapy (RT) treatments limits effective dose escalation in the tumor to achieve nominal treatment results. Gold nanoparticles (GNPs) as radiosensitizing agents to locally increase photoelectron production have gained interest as a safe and viable method to improve therapeutic results. Among many other factors, the dose rate of the incident radiation has been shown to affect the radiosensitizing properties of GNPs significantly. PURPOSE: To evaluate GNP-induced radiosensitization during variable dose rate delivery from the decay of a high dose rate brachytherapy 192-Ir source and a clinical 6MV linear accelerator (LINAC).
methodsHEC-1A endometrial cancer cells were seeded into 35mm petri dishes with or without 10µg/mL with spherical 11nm GNPs functionalized with polyethylene glycol and integrin binding domain RGD to improve intracellular uptake. Variable dose rate delivery from the 192-Ir source was achieved at two source strengths of 37.95 mGy m
resultsGNP-induced radiosensitization was significantly greater with higher dose rates than lower. Clonogenic loss with GNPs was increased from 1.00 to 1.19 (p < 0.001) with higher dose rates from 192-Ir source and from 1.03 to 1.16 (p < 0.001) with higher dose rate LINAC irradiations. DNA damage increase from GNPs was not significant at lower dose rates for both 192-Ir (p > 0.05) and LINAC (p > 0.05) irradiations; however, DNA damage was significantly increased at higher dose rates (192-Ir: p < 0.01; 6MV: p < 0.05).
conclusionsWe have successfully demonstrated in vitro that clinically plausible GNP concentrations can induce variable radiosensitization based on the administered dose rate from both 192-Ir and LINAC irradiations. This work demands future research into the clinical translation of GNPs into high-dose-rate environments.
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